Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China.
School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, People's Republic of China.
Nanotechnology. 2021 Nov 29;33(8). doi: 10.1088/1361-6528/ac385d.
MXenes are a group of inorganic two-dimensional (2D) nanomaterial, and have raised significant interests in biomedical areas. TiCT, as an important member of MXene family, is widely studied because of its biodegradability and low-cytotoxicity. However, their single antibacterial mechanism and poor stability in aqueous solution need to be improved, especially for the antimicrobial applications. In this work, a MXene-based hybrid antibacterial system (M-HAS) was developed and its synergistic antibacterial activity was investigated. In the M-HAS, 2D few-layer TiCT(FL-TiCT) was modified with hydrophilic polymers and thereby used as carriers for silver nanoparticles (Ag NPs). By assembling these two substrates, photodynamic performance of the prepared system is significantly improved with a large amount of reactive oxygen species produced under 660 nm laser. Antibacterial effects of the M-HAS are enhanced by over 4 times with irradiation. In another word, the developed hybrid system displays excellent photodynamic antibacterial synergistic properties. This work takes advantage of the photodynamic properties of each component in the M-HAS to achieve efficient antibacterial activity and proposes an innovative approach to develop the 2D FL-TiCT-based antibacterial platform.
MXenes 是一类无机二维（2D）纳米材料，在生物医学领域引起了极大的兴趣。TiCT 作为 MXene 家族的重要成员，由于其可生物降解性和低细胞毒性而被广泛研究。然而，它们单一的抗菌机制和在水溶液中的较差稳定性仍需要得到改善，特别是在抗菌应用方面。在本工作中，开发了一种基于 MXene 的混合抗菌体系（M-HAS），并研究了其协同抗菌活性。在 M-HAS 中，二维少层 TiCT（FL-TiCT）被亲水性聚合物修饰，从而用作银纳米颗粒（Ag NPs）的载体。通过组装这两种基底，所制备的体系在 660nm 激光下产生大量活性氧，其光动力性能显著提高。光照后，M-HAS 的抗菌效果增强了 4 倍以上。换句话说，所开发的混合体系表现出优异的光动力协同抗菌性能。本工作利用 M-HAS 中每个组分的光动力特性实现了高效的抗菌活性，并提出了一种创新的方法来开发基于二维 FL-TiCT 的抗菌平台。
