线粒体在细胞衰老中的作用。
The role of mitochondria in cellular senescence.
机构信息
Aging Institute, University of Pittsburgh School of Medicine/UPMC, Pittsburgh, Pennsylvania, USA.
出版信息
FASEB J. 2021 Dec;35(12):e21991. doi: 10.1096/fj.202101462R.
Abstract
Mitochondria are intimately connected to cell fate and function. Here, we review how these intracellular organelles participate in the induction and maintenance of the senescent state. In particular, we discuss how alterations in mitochondrial metabolism, quality control and dynamics are all involved in various aspects of cellular senescence. Together, these observations suggest that mitochondria are active participants and are mechanistically linked to the unique biology of senescence. We further describe how these insights can be potentially exploited for therapeutic benefit.
摘要
线粒体与细胞命运和功能密切相关。在这里，我们回顾了这些细胞内细胞器如何参与诱导和维持衰老状态。特别是，我们讨论了线粒体代谢、质量控制和动力学的改变如何参与细胞衰老的各个方面。这些观察结果表明，线粒体是积极的参与者，并在机制上与衰老的独特生物学相关联。我们进一步描述了如何利用这些见解来获得治疗益处。
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