Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; The Karsh Division of Gastroenterology and Hepatology, Department of Medicine Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; F. Widjaja Foundation Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; The Karsh Division of Gastroenterology and Hepatology, Department of Medicine Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Immunity. 2021 Nov 9;54(11):2442-2444. doi: 10.1016/j.immuni.2021.10.014.
Fungal proteases are well-known allergens. In this issue of Immunity, Wu et al. (2021) observe that allergic airway responses to Candida albicans are mediated by the peptide toxin candidalysin rather than proteases. Candidalysin promotes these responses by stimulating platelets to release the Wnt antagonist Dickkopf-1.
真菌蛋白酶是众所周知的过敏原。在本期《免疫》中，Wu 等人（2021 年）观察到对白念珠菌的过敏气道反应是由肽毒素念珠菌溶血素介导的，而不是蛋白酶。念珠菌溶血素通过刺激血小板释放 Wnt 拮抗剂 Dickkopf-1 来促进这些反应。
