Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan; Laboratory of Brain Imaging and Neural Dynamics (BIND Lab), Chang Gung University, Taoyuan, Taiwan.
Washington University School of Medicine, Program in Occupational Therapy & Department of Neurology, St. Louis, MO, USA.
Neurosci Lett. 2022 Jan 1;766:136336. doi: 10.1016/j.neulet.2021.136336. Epub 2021 Nov 7.
Accumulated evidence has revealed that bilateral superior temporal gyrus (STG), inferior frontal gyrus (IFG), and inferior parietal lobule (IPL) are involved in the processes of sensory gating (SG). However, it remains unknown which neural correlate(s) of SG specifically reflect individuals' perceptual experiences, as measured by the Sensory Gating Inventory (SGI). Thus, this study aims to investigate the relationship of SGI with cortical SG-related regions. Furthermore, we examine whether SG hemispheric asymmetry exists, which is still an inconclusive issue.
Twenty-two healthy young adults performed the auditory paired-stimulus paradigm during magnetoencephalographic recordings. SG of M50 and M100 was measured as ratios (S2/S1) and differences (S1-S2). They were also evaluated with SGI, which factored into three categories of Perceptual Modulation, Distractibility, and Over-Inclusion. SG in the STG, IFG, and IPL were compared between left and right hemispheres, and were used to determine the relationship with SGI.
Only M100 SG differences (S1-S2) of the right IFG were significantly correlated with scores of Perceptual Modulation (partial r = -0.392, p = 0.040) and total SGI scores (partial r = -0.387, p = 0.041). However, we did not find significant lateralization of M50 SG and M100 SG in any studying region.
The individual's perceptual experience is specifically related to electrophysiological SG function of the right IFG.
越来越多的证据表明双侧颞上回（STG）、额下回（IFG）和顶下小叶（IPL）参与了感觉门控（SG）过程。然而，目前尚不清楚 SG 的哪些神经相关物（neural correlate(s)）可以具体反映个体的感知体验，这种感知体验由感觉门控量表（Sensory Gating Inventory，SGI）进行测量。因此，本研究旨在探究 SGI 与皮质 SG 相关区域的关系。此外，我们还研究了 SG 是否存在半球不对称性，这仍然是一个尚未定论的问题。
22 名健康的年轻成年人在进行脑磁图记录时，完成了听觉成对刺激范式。M50 和 M100 的 SG 通过比率（S2/S1）和差值（S1-S2）进行测量。他们还接受了 SGI 的评估，该量表分为感知调制、分心和过度包容三个类别。比较了左右半球的 STG、IFG 和 IPL 中的 SG，并将其与 SGI 进行关联分析。
仅右侧 IFG 的 M100 SG 差值（S1-S2）与感知调制的评分（部分 r=-0.392，p=0.040）和 SGI 总分（部分 r=-0.387，p=0.041）显著相关。然而，我们并未发现任何研究区域中 M50 SG 和 M100 SG 的显著偏侧化。
个体的感知体验与右侧 IFG 的电生理 SG 功能密切相关。
