Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, Chang Gung University, Taoyuan, Taiwan.
Laboratory of Brain Imaging and Neural Dynamics - BIND Lab, Chang Gung University, Taoyuan, Taiwan.
J Alzheimers Dis. 2024;100(1):175-192. doi: 10.3233/JAD-231257.
Multidomain intervention may delay or ameliorate cognitive decline in older adults at risk of Alzheimer's disease, particularly in the memory and inhibitory functions. However, no study systematically investigates the changes of brain function in cognitively-normal elderly with subjective cognitive decline (SCD) when they receive multidomain intervention.
We aimed to examine whether a multidomain intervention could improve neuropsychological function and neurophysiological activities related to memory and inhibitory function in SCD subjects.
Eight clusters with a total of 50 community-dwelling SCD older adults were single-blind, randomized into intervention group, which received physical and cognitive training, or control group, which received treatment as usual. For the neuropsychological function, a composite Z score from six cognitive tests was calculated and compared between two groups. For the neurophysiological activities, event-related potentials (ERPs) of memory function, including mismatch negativity (MMN) and memory-P3, as well as ERPs of inhibitory function, including sensory gating (SG) and inhibition-P3, were measured. Assessments were performed at baseline (T1), end of the intervention (T2), and 6 months after T2 (T3).
For the neuropsychological function, the effect was not observed after the intervention. For the neurophysiological activities, improved MMN responses of ΔT2-T1 were observed in the intervention group versus the control group. The multidomain intervention produced a sustained effect on memory-P3 latencies of ΔT3-T1. However, there were no significant differences in changes of SG and inhibition-P3 between intervention and control groups.
While not impactful on neuropsychological function, multidomain intervention enhances specific neurophysiological activities associated with memory function.
多领域干预可能会延迟或改善有阿尔茨海默病风险的老年人的认知能力下降，尤其是在记忆和抑制功能方面。然而，目前尚无研究系统地调查接受多领域干预的有主观认知下降（SCD）的认知正常老年人的大脑功能变化。
我们旨在研究多领域干预是否可以改善 SCD 受试者的神经心理学功能和与记忆及抑制功能相关的神经生理活动。
将 8 个群组（共 50 名）的社区居住的 SCD 老年人进行单盲、随机分组，干预组接受身体和认知训练，对照组接受常规治疗。对于神经心理学功能，计算了 6 项认知测试的综合 Z 分数，并比较了两组之间的差异。对于神经生理活动，测量了记忆功能的事件相关电位（ERPs），包括失匹配负波（MMN）和记忆 P3，以及抑制功能的 ERPs，包括感觉门控（SG）和抑制 P3。评估在基线（T1）、干预结束时（T2）和 T2 后 6 个月（T3）进行。
对于神经心理学功能，干预后未观察到效果。对于神经生理活动，与对照组相比，干预组的 MMN 反应在 T2-T1 时出现改善。多领域干预对 T3-T1 时的记忆 P3 潜伏期产生了持续的影响。然而，干预组和对照组之间的 SG 和抑制 P3 的变化没有显著差异。
虽然多领域干预对神经心理学功能没有影响，但它增强了与记忆功能相关的特定神经生理活动。
