Cook F V, Farrar W E
South Med J. 1978 May;71(5):512-5. doi: 10.1097/00007611-197805000-00011.
Although sulfonamide therapy has reduced the case fatality rate in infection due to Nocardia asteroides from nearly 100% to 25% to 45% there remains a need for a still more effective chemotherapeutic regimen. We describe three cases of serious infection due to N asteroides treated successfully with trimethoprim-sulfamethoxazole (TMP-SMX) and review an additional 15 cases from the world literature. Trimethoprim and sulfamethoxazole exhibit a synergistic interaction in vitro against N asteroides, and the agent reaches antibacterial concentrations in blood, lung, and the central nervous system. Clinical results have been satisfactory in the limited number of patients treated to date.
尽管磺胺类药物疗法已将星形诺卡菌感染的病死率从近100%降至25%至45%，但仍需要一种更有效的化疗方案。我们描述了3例用甲氧苄啶-磺胺甲恶唑（TMP-SMX）成功治疗的严重星形诺卡菌感染病例，并复习了世界文献中的另外15例病例。甲氧苄啶和磺胺甲恶唑在体外对星形诺卡菌表现出协同作用，且该药物在血液、肺和中枢神经系统中可达到抗菌浓度。在迄今治疗的有限数量患者中，临床结果令人满意。
