一种在体内对诺卡菌有效的头孢菌素：头孢噻肟在急性肺诺卡菌病小鼠模型中的疗效。
A cephalosporin active in vivo against Nocardia: efficacy of cefotaxime in murine model of acute pulmonary nocardiosis.
作者信息
Sugar A M, Chahal R S, Stevens D A
出版信息
J Hyg (Lond). 1983 Dec;91(3):421-7. doi: 10.1017/s0022172400060459.
Abstract
Cefotaxime, a cephalosporin drug, has been shown to be active in vitro against nocardiae, a finding confirmed in this study. Pharmacokinetic studies were performed in mice to define regimens which provided peak serum levels comparable to that achieved in man with currently used doses. These regimens were shown to be effective with only short courses of therapy of rapidly progressive and highly lethal N. asteroides infection, produced by pulmonary challenge of mice. This suggests the possible utility of this drug in human nocardiosis.
摘要
头孢噻肟是一种头孢菌素类药物，已证实在体外对诺卡菌具有活性，本研究证实了这一发现。在小鼠身上进行了药代动力学研究，以确定能提供与当前人类使用剂量所达到的峰值血清水平相当的给药方案。这些给药方案在对小鼠进行肺部攻击所产生的快速进展且高度致命的星形诺卡菌感染的短疗程治疗中显示出有效。这表明该药物在人类诺卡菌病中可能具有实用价值。
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本文引用的文献
1
CNS nocardiosis: response to sulfamethoxazole-trimethoprim.
Arch Neurol. 1980 Nov;37(11):729-30. doi: 10.1001/archneur.1980.00500600077017.
2
In-vitro susceptibility of Nocardia and Rhodococcus to fourteen beta-lactam antibiotics.
J Antimicrob Chemother. 1982 Dec;10(6):564-5. doi: 10.1093/jac/10.6.564.
3
Susceptibility of Nocardia asteroides to various antibiotics, including newer beta-lactams, trimethoprim-sulfamethoxazole, amikacin, and N-formimidoyl thienamycin.星形诺卡菌对多种抗生素的敏感性，包括新型β-内酰胺类、甲氧苄啶-磺胺甲恶唑、阿米卡星和N-甲酰亚胺硫霉素。
Antimicrob Agents Chemother. 1982 Jun;21(6):1011-2. doi: 10.1128/AAC.21.6.1011.
4
In vitro susceptibility of Nocardia asteroides to N-formimidoyl thienamycin and several cephalosporins.星形诺卡菌对N-甲酰亚胺硫霉素及几种头孢菌素的体外敏感性
Antimicrob Agents Chemother. 1981 Dec;20(6):841-2. doi: 10.1128/AAC.20.6.841.
5
Effect of route on inoculation on host resistance to Nocardia.接种途径对宿主抗诺卡氏菌能力的影响。
Infect Immun. 1980 Apr;28(1):185-9. doi: 10.1128/iai.28.1.185-189.1980.
6
Successful treatment of Nocardia asteroides infection with amikacin.用阿米卡星成功治疗星形诺卡菌感染。
J Pediatr. 1980 Apr;96(4):771-3. doi: 10.1016/s0022-3476(80)80766-9.
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