一种在体内对诺卡菌有效的头孢菌素：头孢噻肟在急性肺诺卡菌病小鼠模型中的疗效。
A cephalosporin active in vivo against Nocardia: efficacy of cefotaxime in murine model of acute pulmonary nocardiosis.
作者信息
Sugar A M, Chahal R S, Stevens D A
出版信息
J Hyg (Lond). 1983 Dec;91(3):421-7. doi: 10.1017/s0022172400060459.
Abstract
Cefotaxime, a cephalosporin drug, has been shown to be active in vitro against nocardiae, a finding confirmed in this study. Pharmacokinetic studies were performed in mice to define regimens which provided peak serum levels comparable to that achieved in man with currently used doses. These regimens were shown to be effective with only short courses of therapy of rapidly progressive and highly lethal N. asteroides infection, produced by pulmonary challenge of mice. This suggests the possible utility of this drug in human nocardiosis.
摘要
头孢噻肟是一种头孢菌素类药物，已证实在体外对诺卡菌具有活性，本研究证实了这一发现。在小鼠身上进行了药代动力学研究，以确定能提供与当前人类使用剂量所达到的峰值血清水平相当的给药方案。这些给药方案在对小鼠进行肺部攻击所产生的快速进展且高度致命的星形诺卡菌感染的短疗程治疗中显示出有效。这表明该药物在人类诺卡菌病中可能具有实用价值。
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本文引用的文献
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