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羊水乳酸(AFL):难产分娩结局的新预测指标。

Amniotic fluid lactate (AFL): a new predictor of labor outcome in dystocic deliveries.

机构信息

Department of Clinical Science and Education, Karolinska Institute, Soder Hospital, Stockholm, Sweden.

出版信息

J Matern Fetal Neonatal Med. 2022 Dec;35(25):7306-7311. doi: 10.1080/14767058.2021.1946790. Epub 2021 Nov 10.

DOI:10.1080/14767058.2021.1946790
PMID:34758684
Abstract

Even today, hundreds of thousands of women die or suffer high levels of morbidity associated with childbirth. One of the most common causes is halted labor progress, or labor dystocia. There have been no developments in the diagnosis or treatment of dystocic deliveries since Friedman designed the Partogram in the 1950s. Oxytocin is the only treatment for dystocic labor. Sometimes, oxytocin is a lifesaver for the woman, especially in severe postpartum hemorrhages. At the same time, it is also one of the most overused drugs in obstetric care. This review article is meant to provide a short overview of the current knowledge of uterine metabolism during labor, uterine lactate production, and its association with labor dystocia. The article also intends to reflect new ways of thinking regarding practical recommendations for treating labor dystocia and offer a look at the future of dystocic labor management.

摘要

即使在今天,仍有成千上万的女性死于分娩相关的高发病率,或因分娩并发症而遭受严重的健康问题。其中最常见的原因之一是产程停滞,也就是难产。自弗里德曼(Friedman)在 20 世纪 50 年代设计产程图以来,难产的诊断和治疗方法没有任何进展。催产素是治疗难产的唯一方法。有时,催产素是女性的救命稻草,尤其是在严重的产后出血情况下。同时,它也是产科护理中最滥用的药物之一。本文旨在提供分娩时子宫代谢、子宫乳酸生成及其与难产关系的最新知识的简要概述。文章还试图反映治疗难产的实际建议的新思维方式,并展望难产管理的未来。

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Amniotic fluid lactate (AFL): a new predictor of labor outcome in dystocic deliveries.羊水乳酸(AFL):难产分娩结局的新预测指标。
J Matern Fetal Neonatal Med. 2022 Dec;35(25):7306-7311. doi: 10.1080/14767058.2021.1946790. Epub 2021 Nov 10.
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Lactate in Amniotic Fluid: Predictor of Labor Outcome in Oxytocin-Augmented Primiparas' Deliveries.羊水乳酸:缩宫素增强分娩初产妇分娩结局的预测指标
PLoS One. 2016 Oct 26;11(10):e0161546. doi: 10.1371/journal.pone.0161546. eCollection 2016.
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A randomized controlled trial of a new treatment for labor dystocia.一项关于产程难产新疗法的随机对照试验。
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Body mass index and labor outcome associated with the level of amniotic fluid lactate. .体重指数和分娩结局与羊水乳酸水平相关。
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Elevated amniotic fluid lactate predicts labor disorders and cesarean delivery in nulliparous women at term.足月初产妇羊水中乳酸水平升高可预测分娩障碍和剖宫产。
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[Effects of a policy for reasonable use of oxytocin during spontaneous labor at term].[足月自然分娩时合理使用缩宫素政策的效果]
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ACOG technical bulletin. Dystocia and the augmentation of labor. Number 218--December 1995 (replaces no. 137, December 1989, and no. 157, July 1991). American College of Obstetricians and Gynecologists.美国妇产科医师学会技术公报。难产与产程加强。第218号——1995年12月(取代1989年12月第137号和1991年7月第157号)。美国妇产科医师学会。
Int J Gynaecol Obstet. 1996 Apr;53(1):73-80.
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Active management of labor and operative delivery in nulliparous women.初产妇的产程积极管理与手术分娩
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The Pathophysiology of Labor Dystocia: Theme with Variations.分娩难产的病理生理学:主题变奏。
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Maternal and newborn plasma oxytocin levels in response to maternal synthetic oxytocin administration during labour, birth and postpartum - a systematic review with implications for the function of the oxytocinergic system.产妇分娩、生产和产后接受合成催产素治疗时母血和新生儿血中催产素水平变化:一项系统综述——对催产素能系统功能的启示
BMC Pregnancy Childbirth. 2023 Mar 2;23(1):137. doi: 10.1186/s12884-022-05221-w.