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营养在肥胖儿童非酒精性脂肪性肝病治疗中的作用。

The role of nutrition in non-alcoholic fatty liver disease treatment in obese children.

机构信息

Université de Lille, 59000 Lille, France.

Université Paris Descartes, 75006 Paris, France, Groupe Francophone d'Hépatologie Gastroentérologie Nutrition Pédiatrique (GFHGNP).

出版信息

Arch Pediatr. 2022 Jan;29(1):1-11. doi: 10.1016/j.arcped.2021.09.009. Epub 2021 Nov 8.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs mostly in the context of insulin resistance and obesity. It has rapidly evolved into the most common cause of liver disease among children. The incidence is high in obese children and a greater risk of disease progression is associated with severe obesity, highlighting the role of nutrition. To date, there is no consensus on NAFLD management. This is a narrative review of clinical studies on the potential benefit of nutritional interventions, including lifestyle modifications, vitamins, docosahexaenoic acid, and probiotics in children with NAFLD. The Comité de nutrition de la Société Française de Pédiatrie (CN-SFP) emphasizes the effect of limiting added sugar intake, i.e., fructose or sucrose-containing beverages, and promoting physical activity in the care of NAFLD.

摘要

非酒精性脂肪性肝病(NAFLD)是一种高发的慢性肝病,主要发生在胰岛素抵抗和肥胖的背景下。它已迅速成为儿童最常见的肝病病因。肥胖儿童的发病率较高,严重肥胖与疾病进展风险增加相关,突出了营养的作用。迄今为止,NAFLD 管理尚无共识。这是一篇关于营养干预(包括生活方式改变、维生素、二十二碳六烯酸和益生菌)对非酒精性脂肪性肝病儿童潜在益处的临床研究的叙述性综述。法国儿科学会营养委员会(CN-SFP)强调限制添加糖摄入(即含果糖或蔗糖的饮料)和促进体育活动在非酒精性脂肪性肝病护理中的作用。

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