舌鳞状细胞癌中淋巴管和神经周围侵犯的预后价值。

Prognostic value of lymphovascular and perineural invasion in squamous cell carcinoma of the tongue.

机构信息

School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil; Basic and Clinical Dentistry Group, School of Dentistry, CES University, Medellín, Colombia.

Basic Sciences Group, School of Medicine, CES University, Medellín, Colombia.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol. 2022 Feb;133(2):207-215. doi: 10.1016/j.oooo.2021.08.021. Epub 2021 Aug 30.

DOI:10.1016/j.oooo.2021.08.021

PMID:34758940

Abstract

OBJECTIVE

The objective of this study was to investigate the association between survival rate and lymphovascular invasion (LVI) and perineural invasion (PNI) in the tumor invasive front (TIF) of squamous cell carcinoma of the tongue (TSCC).

STUDY DESIGN

Seventy patients with TSCC were included. The retrospective analysis included demographic, clinical, and histopathologic data. Tissue blocks containing the TIF were stained with anti-α-smooth muscle actin and anti-S100 to detect LVI and PNI, respectively. Overall survival (OS) and disease-specific survival (DSS) were assessed using Pearson's chi-square test, Kaplan-Meier method, and Cox regression.

RESULTS

LVI and PNI were detected in 61.4% and 78.6% of the TSCC samples at the TIF, respectively. LVI and PNI were present in 54.3% of the cases and were associated with advanced clinical stage, lymph node resection, metastatic nodes, and lower survival (P < .05). The 5-year OS and DSS rates were 44% and 52%, respectively. Multivariate analysis showed that primary tumors >3.0 cm (hazard ratio = 4.29; P = .004) and a concomitant presence of LVI and PNI at the TIF (hazard ratio = 4.0; P = .012) were independent predictors for worse DSS.

CONCLUSION

LVI and PNI, identified by immunostaining at the TIF, are potential prognostic markers of TSCC.

摘要

目的

本研究旨在探讨舌鳞状细胞癌（TSCC）肿瘤侵袭前沿（TIF）中生存率与淋巴管浸润（LVI）和神经周围浸润（PNI）的相关性。

研究设计

纳入 70 例 TSCC 患者。回顾性分析包括人口统计学、临床和组织病理学数据。用抗α-平滑肌肌动蛋白和抗 S100 分别对包含 TIF 的组织块进行染色，以检测 LVI 和 PNI。采用 Pearson χ2 检验、Kaplan-Meier 法和 Cox 回归评估总生存率（OS）和疾病特异性生存率（DSS）。

结果

在 TIF 处，分别有 61.4%和 78.6%的 TSCC 样本检测到 LVI 和 PNI。54.3%的病例存在 LVI 和 PNI，与临床分期较晚、淋巴结清扫、转移性淋巴结和较低的生存率有关（P<.05）。5 年 OS 和 DSS 率分别为 44%和 52%。多因素分析显示，原发肿瘤＞3.0 cm（危险比=4.29；P=.004）和 TIF 处同时存在 LVI 和 PNI（危险比=4.0；P=.012）是 DSS 较差的独立预测因子。