Department of Medicine and Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Departments of Medicine and Epidemiology, Geisel School of Medicine, Dartmouth University, Hanover, New Hampshire.
Cancer Epidemiol Biomarkers Prev. 2022 Jan;31(1):293-295. doi: 10.1158/1055-9965.EPI-21-0713. Epub 2021 Nov 10.
Sex hormones have been implicated in the etiology of colorectal neoplasia in women for over 40 years, but there has been very little investigation of the role of these hormones in men.
Using data from an adenoma chemoprevention trial, we conducted a secondary analysis to examine serum hormone levels [testosterone, androstenedione, DHEA sulfate (DHEAS), and sex hormone binding globulin (SHBG)] and risk of colorectal precursors in 925 men. Multivariable logistic regression models were fit to evaluate adjusted associations between hormone levels and risk of "low-risk" (single tubular adenoma < 1 cm) and "high-risk" lesions (advanced adenoma or sessile serrated adenoma or right-sided serrated polyp or >2 adenomas of any size).
Overall, levels of free testosterone, total testosterone, androstenedione, DHEAS, or SHBG were not associated with either "low-risk" or "high-risk" early precursor lesions in the colorectum.
These findings do not support the role of sex hormones in early colorectal neoplasia among men.
This large prospective study address a missing gap in knowledge by providing information on the role of sex hormones in colorectal neoplasia in males.
40 多年来，性激素一直被认为与女性结直肠肿瘤的病因有关，但对男性性激素在其中的作用的研究却很少。
我们利用腺瘤化学预防试验的数据进行了二次分析，以检查 925 名男性的血清激素水平[睾酮、雄烯二酮、硫酸脱氢表雄酮(DHEAS)和性激素结合球蛋白(SHBG)]与结直肠前体病变的风险之间的关系。采用多变量逻辑回归模型评估激素水平与“低危”(单发管状腺瘤<1cm)和“高危”病变(高级别腺瘤或平坦型锯齿状腺瘤或右侧锯齿状息肉或>2 个任意大小的腺瘤)风险之间的调整关联。
总体而言，游离睾酮、总睾酮、雄烯二酮、DHEAS 或 SHBG 水平与结直肠的“低危”或“高危”早期前体病变均无关。
这些发现不支持性激素在男性结直肠早期肿瘤发生中的作用。
这项大型前瞻性研究通过提供性激素在男性结直肠肿瘤发生中的作用的信息，填补了知识空白。
