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早产儿甲状腺功能减退症治疗指南。

Guideline for the Treatment of Hypothyroidism in Prematurity.

作者信息

Hashemipour Mahin, Rad Afagh Hassanzadeh, Dalili Setila

机构信息

Department of Pediatrics, School of Medicine, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

出版信息

Int J Prev Med. 2021 Sep 29;12:123. doi: 10.4103/ijpvm.IJPVM_424_20. eCollection 2021.

DOI:10.4103/ijpvm.IJPVM_424_20
PMID:34760134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8551794/
Abstract

Congenital hypothyroidism is one of the most common endocrine disorders in infants and children. Thyroid hormone effects the function of most organs of the body. In premature neonates, thyroid abnormalities are very common but transient. There is a significant difference between the appropriate time for screening in premature and term neonates and there are different viewpoints in treating hypothyroidism in prematurity. According to the probable exceptions in this issue, there is no definite guideline. Therefore, regarding this confusion, this guideline aimed to help clinicians for rapid on-time decision making.

摘要

先天性甲状腺功能减退症是婴幼儿最常见的内分泌疾病之一。甲状腺激素影响身体大多数器官的功能。在早产新生儿中,甲状腺异常非常常见但为一过性。早产和足月儿的适宜筛查时间存在显著差异,并且对于早产患儿甲状腺功能减退症的治疗也存在不同观点。鉴于该问题可能存在的例外情况,尚无明确的指南。因此,针对这种困惑,本指南旨在帮助临床医生快速及时地做出决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aee1/8551794/6d1eff9d961b/IJPVM-12-123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aee1/8551794/6d1eff9d961b/IJPVM-12-123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aee1/8551794/6d1eff9d961b/IJPVM-12-123-g001.jpg

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本文引用的文献

1
Gender disparities in screening for congenital hypothyroidism using thyroxine as a primary screen.用甲状腺素作为初筛指标时先天性甲状腺功能减退症筛查中的性别差异。
Eur J Endocrinol. 2018 Sep;179(3):161-167. doi: 10.1530/EJE-18-0399. Epub 2018 Jun 26.
2
Small for gestational age is a risk factor for the development of delayed thyrotropin elevation in infants weighing less than 2000 g.小于胎龄儿是体重小于 2000 克的婴儿促甲状腺激素升高延迟的危险因素。
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甲状腺激素缺乏减少小鼠海马中的电压门控 Na 电流和 Na/K-ATPase 的表达。
Int J Mol Sci. 2022 Apr 8;23(8):4133. doi: 10.3390/ijms23084133.
三级医疗中心早产儿极低出生体重儿甲状腺功能减退症发生率较高和 TSH 延迟升高。
Horm Res Paediatr. 2018;89(4):224-232. doi: 10.1159/000487637. Epub 2018 Apr 11.
4
Screening of congenital hypothyroidism in preterm, low birth weight and very low birth weight neonates: A systematic review.早产儿、低出生体重儿和极低出生体重儿先天性甲状腺功能减退症的筛查:一项系统综述。
Pediatr Neonatol. 2018 Feb;59(1):3-14. doi: 10.1016/j.pedneo.2017.04.006. Epub 2017 Jul 22.
5
Effect of L-thyroxine supplementation on very low birth weight infants with transient hypothyroxinemia of prematurity at 3 years of age.补充左甲状腺素对3岁极早早产儿伴暂时性甲状腺素缺乏症的影响。
J Perinatol. 2017 May;37(5):602-605. doi: 10.1038/jp.2016.266. Epub 2017 Jan 26.
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Congenital hypothyroidism with delayed thyroid-stimulating hormone elevation in premature infants born at less than 30 weeks gestation.孕30周前出生的早产儿先天性甲状腺功能减退症伴促甲状腺激素升高延迟
J Perinatol. 2017 Mar;37(3):277-282. doi: 10.1038/jp.2016.213. Epub 2016 Dec 1.
7
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Pediatr Radiol. 2014 Aug;44(8):987-96. doi: 10.1007/s00247-014-2911-6. Epub 2014 Mar 27.
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