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[具体物质]在神经元细胞周期中对[相关基因1]、[相关基因2]和[相关基因3]基因表达调控中的可能作用：一项初步研究

Possible Role of in the Regulation of , , and Gene Expression in Neuronal Cell Cycle: A Preliminary Study.

作者信息

Bachtiar Endang W, Septiwidyati Tienneke R

机构信息

Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

出版信息

J Int Soc Prev Community Dent. 2021 Sep 21;11(5):582-587. doi: 10.4103/jispcd.JISPCD_108_21. eCollection 2021 Sep-Oct.

DOI:10.4103/jispcd.JISPCD_108_21
PMID:34760804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8533040/
Abstract

OBJECTIVE

This study aimed at evaluating the effect of exposure in gene expression of (family of transcription factors), cyclin-dependent kinase-1 (), and inducible nitric oxide synthase (iNOS) of the neuronal cell cycle.

MATERIALS AND METHODS

The culture of neuronal cell line SH-SY5Y was exposed to ATCC 33277, and the gene expression of , , and iNOS was analyzed by using a real-time polymerase chain reaction.

RESULTS

It was shown that , a G1 phase biomarker and transcription factor, was upregulated in neuronal cells exposed to compared with that in control cells. However, , a biomarker of G2/M checkpoint and iNOS, was downregulated in neuronal cells exposed to compared with that in control cells.

CONCLUSIONS

can regulate the neuronal cell cycle, as indicated in the , , and gene expression.

摘要

目的

本研究旨在评估暴露于[具体物质名称未明确，暂用“”表示]对神经元细胞周期中（转录因子家族）、细胞周期蛋白依赖性激酶-1（）和诱导型一氧化氮合酶（iNOS）基因表达的影响。

材料与方法

将神经元细胞系SH-SY5Y培养物暴露于美国典型培养物保藏中心33277号菌株（此处“ATCC 33277”可能有误，推测为某种物质），并使用实时聚合酶链反应分析、和iNOS的基因表达。

结果

结果显示，作为G1期生物标志物和转录因子的，在暴露于的神经元细胞中相较于对照细胞上调。然而，作为G2/M期检查点生物标志物的和iNOS，在暴露于的神经元细胞中相较于对照细胞下调。

结论

如、和基因表达所示，可调节神经元细胞周期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/c6ab85e9f070/JISPCD-11-582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/a7b04ec5d1f6/JISPCD-11-582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/06aef4ec07ee/JISPCD-11-582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/c6ab85e9f070/JISPCD-11-582-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/a7b04ec5d1f6/JISPCD-11-582-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/06aef4ec07ee/JISPCD-11-582-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c8/8533040/c6ab85e9f070/JISPCD-11-582-g003.jpg

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