红细胞衍生的线粒体：狼疮中的一个意想不到的干扰素诱导物。
Erythrocyte-derived mitochondria: an unexpected interferon inducer in lupus.
机构信息
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
出版信息
Trends Immunol. 2021 Dec;42(12):1054-1056. doi: 10.1016/j.it.2021.10.010. Epub 2021 Nov 8.
PMID:34764015
Abstract
Type 1 interferon (IFN) is a major contributor to the pathogenesis of systemic lupus erythematosus (SLE). A landmark study by Caielli et al. now shows that erythrocytes from lupus patients that fail to switch from glycolysis to oxidative phosphorylation during differentiation retain their mitochondria. These mitochondria-containing erythrocytes represent a novel source of IFN when phagocytosed by macrophages.
摘要
1 型干扰素 (IFN) 是系统性红斑狼疮 (SLE) 发病机制的主要贡献者。Caielli 等人的一项里程碑式研究表明，在分化过程中无法从糖酵解转变为氧化磷酸化的狼疮患者红细胞保留其线粒体。当这些含线粒体的红细胞被巨噬细胞吞噬时，它们代表了 IFN 的一个新来源。
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