Wang Chao, Chen Bingxing, Yu Xiaochen, Guan Xiuru
Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, NanGang, Harbin, 150001, Heilongjiang, People's Republic of China.
Clin Rev Allergy Immunol. 2025 Feb 7;68(1):10. doi: 10.1007/s12016-025-09025-6.
Systemic lupus erythematosus (SLE) is an autoimmune disease that significantly increases the risk of cardiovascular diseases, particularly atherosclerosis (AS). Understanding the shared pathogenic mechanisms underlying SLE and AS is crucial for developing effective therapeutic strategies. Macrophages, as pivotal immune cells, play a critical role in the initiation and progression of atherosclerotic plaques within the context of SLE. This review delves into the molecular and cellular mechanisms governing macrophage activation and differentiation in response to SLE-related inflammatory mediators, highlighting their roles in lipid metabolism, plaque stability, and immune regulation. Additionally, we discussed the current treatment modalities for SLE and their impact on macrophage functionality, exploring these effects for atherosclerotic progression. By elucidating the intricate relationship between macrophages, SLE pathophysiology, and AS progression, this review underscores the need for a multidisciplinary approach in managing SLE and its cardiovascular complications, aiming to improve patient survival and quality of life through tailored therapeutic interventions addressing both autoimmune and cardiovascular pathologies.
系统性红斑狼疮（SLE）是一种自身免疫性疾病，会显著增加心血管疾病的风险，尤其是动脉粥样硬化（AS）。了解SLE和AS共同的致病机制对于制定有效的治疗策略至关重要。巨噬细胞作为关键的免疫细胞，在SLE背景下动脉粥样硬化斑块的发生和发展中起关键作用。本综述深入探讨了巨噬细胞在响应SLE相关炎症介质时的激活和分化的分子和细胞机制，强调了它们在脂质代谢、斑块稳定性和免疫调节中的作用。此外，我们讨论了SLE的当前治疗方式及其对巨噬细胞功能的影响，探讨了这些影响对动脉粥样硬化进展的作用。通过阐明巨噬细胞、SLE病理生理学和AS进展之间的复杂关系，本综述强调了在管理SLE及其心血管并发症时采用多学科方法的必要性，旨在通过针对自身免疫和心血管疾病的定制治疗干预措施来提高患者的生存率和生活质量。
