慢性排痰症状对非结核分枝杆菌肺病患者生活质量的影响：一项横断面研究。

Influence of chronic sputum symptoms on quality of life in patients with nontuberculous mycobacterial pulmonary disease: A cross-sectional study.

机构信息

Department of Clinical Mycobacteriology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan; Respiratory Care and Rehabilitation Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo, 204-8522, Japan.

Respiratory Diseases Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo, 204-8522, Japan; Department of Basic Mycobacteriology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan.

出版信息

Respir Investig. 2022 Mar;60(2):277-283. doi: 10.1016/j.resinv.2021.09.011. Epub 2021 Nov 8.

DOI:10.1016/j.resinv.2021.09.011

PMID:34764045

Abstract

BACKGROUND

The effect of chronic sputum (CS) symptoms on health-related quality of life (HRQOL) in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been studied. The aim of this study was to clarify the differences in the clinical characteristics of NTM-PD patients with and without CS and to investigate the effect of CS on HRQOL.

METHODS

This cross-sectional study included patients with NTM-PD who were prescribed pulmonary rehabilitation at the Fukujuji Hospital from March 2016 to June 2019. HRQOL was evaluated using the MOS 36-Item Short-Form Health Survey (SF-36).

RESULTS

Of the 99 subjects studied, 71 had CS (CS+) (71.7%), and 28 (28.3%) did not have CS (CS-). Patients in the CS + group had a lower body mass index, forced vital capacity percent predicted, and forced expiratory volume in 1 s percent predicted. Regarding the radiological evaluation, the proportion of patients with the fibrocavitary form and the radiological score were significantly higher in the CS + group. The mental component summary (MCS) score of the SF-36 were significantly lower in the CS + group. Multiple regression analysis showed that the presence of CS was independently associated with a lower MCS score of the SF-36.

CONCLUSIONS

NTM-PD patients with CS had more severe disease, with reduced pulmonary function and severe radiological findings. CS was shown to independently affect HRQOL, especially mental status.

摘要

背景

慢性排痰（CS）症状对非结核分枝杆菌肺病（NTM-PD）患者的健康相关生活质量（HRQOL）的影响尚未得到研究。本研究旨在阐明有无 CS 的 NTM-PD 患者的临床特征差异，并探讨 CS 对 HRQOL 的影响。

方法

本横断面研究纳入了 2016 年 3 月至 2019 年 6 月在福聚寺医院接受肺康复治疗的 NTM-PD 患者。采用 MOS 36-Item 短式健康调查量表（SF-36）评估 HRQOL。

结果

在 99 名研究对象中，71 名（71.7%）有 CS（CS+），28 名（28.3%）无 CS（CS-）。CS+组患者的体重指数、用力肺活量预计值和 1 秒用力呼气量预计值较低。在影像学评估方面，CS+组中纤维空洞型和影像学评分的患者比例明显更高。SF-36 的精神成分综合评分（MCS）在 CS+组中明显较低。多因素回归分析显示，CS 的存在与 SF-36 的 MCS 评分降低独立相关。