Division of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea.
Yonsei University Graduate School of Medicine, Seoul, Republic of Korea.
BMC Infect Dis. 2024 Jun 19;24(1):604. doi: 10.1186/s12879-024-09499-3.
Although the Mini Nutritional Assessment (MNA) is recognized as a useful tool for evaluating nutritional status in patients with various diseases, its applicability in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) remains undetermined.
We designed a prospective cross-sectional study to investigate whether the MNA Short-Form (MNA-SF) score can serve as a screening tool to assess the nutritional status of patients with NTM-PD. The MNA-SF was conducted upon patient enrollment, and correlation analyses were performed to compare MNA-SF scores with other nutritional measurements and disease severity. Multivariable logistic regression analyses were conducted to evaluate the association between MNA-SF scores and NTM-PD severity.
The 194 patients with NTM-PD included in the analysis had a median age of 65.0 (59.0-69.0) years; 59.3% (n = 115) had low MNA-SF scores (< 12). The low MNA-SF group exhibited a lower body mass index (19.7 vs. 22.4 kg/m, p < 0.001) and fat-free mass index (14.7 vs. 15.6 kg/m, p < 0.001) than the normal MNA-SF group, as well as higher incidences of sarcopenia (20.0% vs. 6.3%, p = 0.008) and adipopenia (35.7% vs. 5.1%, p < 0.001). However, no significant differences in calorie and protein intakes were observed between the two groups. Low MNA-SF scores were associated with radiographic severity (adjusted odds ratio 2.72, 95% confidence interval 1.38-5.36) but not with forced vital capacity.
The MNA-SF can effectively assess the nutritional status of patients with NTM-PD and can serve as an important clinical indicator in NTM-PD where treatment timing is determined by clinical judgment.
尽管微型营养评估（MNA）被认为是评估各种疾病患者营养状况的有用工具，但它在非结核分枝杆菌肺病（NTM-PD）患者中的适用性仍未确定。
我们设计了一项前瞻性横断面研究，以调查 MNA 短表（MNA-SF）评分是否可用作评估 NTM-PD 患者营养状况的筛选工具。在患者入组时进行 MNA-SF 评估，并进行相关分析，以比较 MNA-SF 评分与其他营养测量和疾病严重程度的相关性。进行多变量逻辑回归分析，以评估 MNA-SF 评分与 NTM-PD 严重程度之间的关联。
在分析中纳入的 194 例 NTM-PD 患者的中位年龄为 65.0（59.0-69.0）岁；59.3%（n=115）的 MNA-SF 评分较低（<12）。低 MNA-SF 组的体重指数（19.7 与 22.4 kg/m2，p<0.001）和去脂体重指数（14.7 与 15.6 kg/m2，p<0.001）均低于正常 MNA-SF 组，且肌少症（20.0%与 6.3%，p=0.008）和脂肪减少症（35.7%与 5.1%，p<0.001）的发生率更高。然而，两组之间的热量和蛋白质摄入量没有显著差异。低 MNA-SF 评分与放射学严重程度相关（调整后的优势比 2.72，95%置信区间 1.38-5.36），但与用力肺活量无关。
MNA-SF 可有效评估 NTM-PD 患者的营养状况，并可作为决定治疗时机的临床判断中 NTM-PD 的重要临床指标。
