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Dysregulated neutrophilic cell death in SLE: a spotlight on ferroptosis.

作者信息

Ohl Kim, Rauen Thomas, Tenbrock Klaus

机构信息

Dept. of Pediatrics, RWTH Aachen University, 52074, Aachen, Germany.

Division of Nephrology and Clinical Immunology, RWTH Aachen University, 52074, Aachen, Germany.

出版信息

Signal Transduct Target Ther. 2021 Nov 11;6(1):392. doi: 10.1038/s41392-021-00804-z.

DOI:10.1038/s41392-021-00804-z
PMID:34764247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8586233/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f8e/8586233/3d44593bfe5c/41392_2021_804_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f8e/8586233/3d44593bfe5c/41392_2021_804_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f8e/8586233/3d44593bfe5c/41392_2021_804_Fig1_HTML.jpg

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本文引用的文献

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Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity.谷胱甘肽过氧化物酶4调节的中性粒细胞铁死亡诱导全身自身免疫。
Nat Immunol. 2021 Sep;22(9):1107-1117. doi: 10.1038/s41590-021-00993-3. Epub 2021 Aug 12.
2
Ferroptosis: mechanisms, biology and role in disease.铁死亡:机制、生物学及其在疾病中的作用
Nat Rev Mol Cell Biol. 2021 Apr;22(4):266-282. doi: 10.1038/s41580-020-00324-8. Epub 2021 Jan 25.
3
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus.
系统性红斑狼疮中线粒体功能和程序性细胞死亡相关关键生物标志物及circRNA-miRNA-mRNA调控网络的鉴定
Front Mol Biosci. 2025 Apr 14;12:1586294. doi: 10.3389/fmolb.2025.1586294. eCollection 2025.
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Exploring Neutrophil Heterogeneity and Plasticity in Health and Disease.探索健康与疾病中的中性粒细胞异质性和可塑性。
Biomedicines. 2025 Mar 1;13(3):597. doi: 10.3390/biomedicines13030597.
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Identification of as a Key Biomarker Linking Iron Metabolism and Dendritic Cell Activation in Systemic Lupus Erythematosus Through Bioinformatics and Experimental Validation.通过生物信息学和实验验证鉴定[具体物质名称未给出]作为系统性红斑狼疮中铁代谢与树突状细胞活化之间联系的关键生物标志物
J Inflamm Res. 2025 Mar 14;18:3859-3878. doi: 10.2147/JIR.S500115. eCollection 2025.
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Iron metabolism in rheumatic diseases.风湿性疾病中的铁代谢
J Transl Autoimmun. 2025 Jan 4;10:100267. doi: 10.1016/j.jtauto.2025.100267. eCollection 2025 Jun.
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J Clin Invest. 2005 Apr;115(4):996-1005. doi: 10.1172/JCI22854.
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Nrf2-deficient female mice develop lupus-like autoimmune nephritis.Nrf2基因缺陷的雌性小鼠会患上狼疮样自身免疫性肾炎。
Kidney Int. 2001 Oct;60(4):1343-53. doi: 10.1046/j.1523-1755.2001.00939.x.