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首次观察到心肌间质中渗透中性钠的积累。

The first observation of osmotically neutral sodium accumulation in the myocardial interstitium.

机构信息

P.N.Lebedev Physical Institute RAS, 53 Leninsky Prospekt, Moscow, 119991, Russia.

Pirogov Russian National Research Medical University, 1 Ostrovitianov St., Moscow, 117997, Russia.

出版信息

Sci Rep. 2021 Nov 11;11(1):22025. doi: 10.1038/s41598-021-01443-8.

DOI:10.1038/s41598-021-01443-8
PMID:34764351
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8585917/
Abstract

The aim of this study was the detection and quantification of the Na depositions in the extracellular matrix of myocardial tissue, which are suggested to be bound by negatively charged glycosaminoglycan (GAG) structures. The presented experimental results are based on high resolution X-ray fluorescence (XRF) spectromicroscopy technique used to perform a comparative analysis of sodium containment in intracellular and interstitial spaces of cardiac tissues taken from animals selected by low and high sodium intake rates. The experimental results obtained show that high sodium daily intake can result in a remarkable increase of sodium content in the myocardial interstitium.

摘要

本研究旨在检测和定量心肌组织细胞外基质中的钠离子沉积，这些钠离子被认为与带负电荷的糖胺聚糖 (GAG) 结构结合。所呈现的实验结果基于高分辨率 X 射线荧光 (XRF) 光谱显微镜技术，用于对低钠和高钠摄入率动物心脏组织的细胞内和细胞间隙中钠含量进行比较分析。实验结果表明，高钠日摄入量可导致心肌间质中钠含量显著增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/1dab7e2b34b6/41598_2021_1443_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/ea35c1fa8f5f/41598_2021_1443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/9c2533c7e7c3/41598_2021_1443_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/ac7c1a1dd5bb/41598_2021_1443_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/f6b702293b0a/41598_2021_1443_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/1dab7e2b34b6/41598_2021_1443_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/ea35c1fa8f5f/41598_2021_1443_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/9c2533c7e7c3/41598_2021_1443_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/ac7c1a1dd5bb/41598_2021_1443_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/f6b702293b0a/41598_2021_1443_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e207/8585917/1dab7e2b34b6/41598_2021_1443_Fig5_HTML.jpg

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