Mohammed Atheer M, Khardali Ibrahim A, Oraiby Magbool E, Hakami Abdulrahman F, Shaheen Emad S, Ageel Ibrahim M, Abutawil Eyas H, Abu-Taweel Gasem M
Department of Biology, College of Sciences, Jazan University, P.O. Box 2079, Jazan 45142, Saudi Arabia.
Poison Control and Medical Forensic Chemistry, Jazan, Saudi Arabia.
Saudi J Biol Sci. 2021 Nov;28(11):6097-6111. doi: 10.1016/j.sjbs.2021.08.085. Epub 2021 Sep 1.
Cannabis is an annual herbaceous plant sometimes grown for decoration and used as bird food that looks like flax. The study wanted to determine if a Cannabis extract may have an effect on how anxious and depressed the female mice behaved. forty healthy female mice were divided into four groups. Tap water was administered to the first group (control). Ethanol was administered to second group (positive control). The third and four groups were given 1 and 2 mg/kg cannabis extract respectively. Treatment continued for 14 days. After therapy, the light-dark chamber, forced swimming, tail suspension, plus lamb and open field tests were done to assess anxiety and depressive behavior. The results indicated that the anxiety and depression were increased in treated females significantly compared to control. Biochemical results showed that DA,5-HT, AChE, GSH, GST, CAT and SOD were decreased while TBARS, corticosterone and cortisol were increased. In conclusion, cannabis effects this kind of females' behavior but the mechanisms are not clear yet. We need more researches on this trend.
大麻是一种一年生草本植物，有时种植用于装饰并用作鸟类食物，其外观类似亚麻。该研究旨在确定大麻提取物是否可能对雌性小鼠的焦虑和抑郁行为产生影响。40只健康雌性小鼠被分为四组。第一组（对照组）给予自来水。第二组（阳性对照组）给予乙醇。第三组和第四组分别给予1毫克/千克和2毫克/千克的大麻提取物。治疗持续14天。治疗后，进行明暗箱、强迫游泳、悬尾、高架十字迷宫和旷场试验以评估焦虑和抑郁行为。结果表明，与对照组相比，接受治疗的雌性小鼠的焦虑和抑郁显著增加。生化结果显示，多巴胺、5-羟色胺、乙酰胆碱酯酶、谷胱甘肽、谷胱甘肽S-转移酶、过氧化氢酶和超氧化物歧化酶减少，而丙二醛、皮质酮和皮质醇增加。总之，大麻会影响这类雌性小鼠的行为，但其机制尚不清楚。我们需要对此趋势进行更多研究。
