• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在1例新冠病毒疫苗接种后严重难治性免疫性血小板减少症患者中，霉酚酸酯联合罗米司亭治疗反应迅速

Rapid response to mycophenolate mofetil in combination with romiplostim in a case of severe refractory immune thrombocytopenia post COVID-19 vaccination.

作者信息

Nutalapati Snigdha, Gupta Garima, Hildebrandt Gerhard C

机构信息

Division of Hematology and Oncology University of Kentucky College of Medicine Lexington Kentucky USA.

出版信息

Clin Case Rep. 2021 Nov 6;9(11):e05035. doi: 10.1002/ccr3.5035. eCollection 2021 Nov.

DOI:10.1002/ccr3.5035
PMID:34765210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8572335/
Abstract

Vaccine mediated immune mediated thrombocytopenia (ITP) is exceedingly rare. We present a case of a young female who developed severe refractory ITP with multiple bleeding sites post second dose of COVID-19 vaccination. She was treated with a combination of romiplostim and mycophenolate mofetil that resulted in rapid platelet count recovery.

摘要

疫苗介导的免疫性血小板减少症（ITP）极为罕见。我们报告一例年轻女性病例，该患者在接种第二剂新冠疫苗后出现严重难治性ITP，并伴有多处出血部位。她接受了罗米司亭和霉酚酸酯联合治疗，血小板计数迅速恢复。

相似文献

1
Rapid response to mycophenolate mofetil in combination with romiplostim in a case of severe refractory immune thrombocytopenia post COVID-19 vaccination.在1例新冠病毒疫苗接种后严重难治性免疫性血小板减少症患者中，霉酚酸酯联合罗米司亭治疗反应迅速
Clin Case Rep. 2021 Nov 6;9(11):e05035. doi: 10.1002/ccr3.5035. eCollection 2021 Nov.
2
Severe, Refractory Immune Thrombocytopenia Occurring After SARS-CoV-2 Vaccine.新型冠状病毒2疫苗接种后发生的严重、难治性免疫性血小板减少症
J Blood Med. 2021 Apr 6;12:221-224. doi: 10.2147/JBM.S307047. eCollection 2021.
3
Refractory severe idiopathic thrombocytopenia and treatment challenges.难治性重度特发性血小板减少症及其治疗挑战
Ann Med Surg (Lond). 2023 Mar 27;85(4):973-975. doi: 10.1097/MS9.0000000000000233. eCollection 2023 Apr.
4
Immune Thrombocytopenia Exacerbation After COVID-19 Vaccination in a Young Woman.一名年轻女性接种新冠疫苗后免疫性血小板减少症加重
Cureus. 2021 Sep 13;13(9):e17942. doi: 10.7759/cureus.17942. eCollection 2021 Sep.
5
Use of romiplostim in a hemodialysis patient with primary immune thrombocytopenia.罗米司亭在一名原发性免疫性血小板减少症血液透析患者中的应用。
Ann Pharmacother. 2012 Nov;46(11):e31. doi: 10.1345/aph.1R134. Epub 2012 Oct 31.
6
Effects of COVID-19 vaccination on platelet counts and bleeding in children, adolescents, and young adults with immune thrombocytopenia.COVID-19 疫苗接种对儿童、青少年和青年免疫性血小板减少症患者血小板计数和出血的影响。
Pediatr Blood Cancer. 2023 Jan;70(1):e30051. doi: 10.1002/pbc.30051. Epub 2022 Nov 1.
7
Severe romiplostim-induced rebound thrombocytopenia after splenectomy for refractory ITP.脾切除术后因难治性免疫性血小板减少症使用罗米司亭治疗导致严重的反弹性血小板减少症
Ann Pharmacother. 2015 Jan;49(1):140-4. doi: 10.1177/1060028014555540. Epub 2014 Oct 16.
8
Use of Romiplostim during pregnancy as a rescue therapy in primary immune thrombocytopenia: Literature review and case description.妊娠期间使用罗米司亭作为原发性免疫性血小板减少症的抢救治疗：文献复习和病例描述。
Platelets. 2020;31(3):403-406. doi: 10.1080/09537104.2019.1615613. Epub 2019 May 22.
9
Mycophenolate Mofetil for First-Line Treatment of Immune Thrombocytopenia.霉酚酸酯用于一线治疗免疫性血小板减少症。
N Engl J Med. 2021 Sep 2;385(10):885-895. doi: 10.1056/NEJMoa2100596.
10
Severe Refractory Immune Thrombocytopenia Successfully Treated with High-Dose Pulse Cyclophosphamide and Eltrombopag.大剂量脉冲环磷酰胺联合艾曲泊帕成功治疗重症难治性免疫性血小板减少症
Case Rep Hematol. 2015;2015:583451. doi: 10.1155/2015/583451. Epub 2015 Jun 9.

引用本文的文献

1
COVID-19-induced immune thrombocytopenia management approach: A case report and literature review.新型冠状病毒肺炎（COVID-19）所致免疫性血小板减少症的管理方法：一例病例报告及文献综述
Clin Case Rep. 2024 Jun 14;12(6):e9070. doi: 10.1002/ccr3.9070. eCollection 2024 Jun.
2
Immune thrombocytopenic purpura secondary to COVID-19 vaccination: A systematic review.COVID-19 疫苗接种相关免疫性血小板减少性紫癜：一项系统评价。
Eur J Haematol. 2023 Apr;110(4):335-353. doi: 10.1111/ejh.13917. Epub 2022 Dec 30.

本文引用的文献

1
Immune thrombocytopenia following COVID-19 mRNA vaccine: casuality or causality?新冠病毒mRNA疫苗接种后的免疫性血小板减少症：是因果关系还是因果关联？
Intern Emerg Med. 2022 Jan;17(1):295-297. doi: 10.1007/s11739-021-02778-w. Epub 2021 Jun 7.
2
Secondary immune thrombocytopenia supposedly attributable to COVID-19 vaccination.继发于 COVID-19 疫苗接种的免疫性血小板减少症。
BMJ Case Rep. 2021 May 31;14(5):e242220. doi: 10.1136/bcr-2021-242220.
3
Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination.辉瑞和莫德纳新冠疫苗接种后出现的血小板减少症。
Am J Hematol. 2021 May 1;96(5):534-537. doi: 10.1002/ajh.26132. Epub 2021 Mar 9.
4
Immune thrombocytopenia in a 22-year-old post Covid-19 vaccine.一名22岁接种新冠疫苗后出现的免疫性血小板减少症。
Am J Hematol. 2021 May 1;96(5):E133-E134. doi: 10.1002/ajh.26106. Epub 2021 Feb 11.
5
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.两种基于 RNA 的新冠候选疫苗的安全性和免疫原性。
N Engl J Med. 2020 Dec 17;383(25):2439-2450. doi: 10.1056/NEJMoa2027906. Epub 2020 Oct 14.
6
The Impact of the Microbiome on Immunity to Vaccination in Humans.微生物组对人类疫苗接种免疫的影响。
Cell Host Microbe. 2020 Aug 12;28(2):169-179. doi: 10.1016/j.chom.2020.06.014.
7
Combination of thrombopoietin receptor agonists, immunosuppressants and intravenous immunoglobulin as treatment of severe refractory immune thrombocytopenia in adults and children.血小板生成素受体激动剂、免疫抑制剂和静脉注射免疫球蛋白联合治疗成人和儿童严重难治性免疫性血小板减少症。
Br J Haematol. 2020 Apr;189(2):e37-e40. doi: 10.1111/bjh.16426. Epub 2020 Feb 24.
8
Fostamatinib for the treatment of chronic immune thrombocytopenia.福他替尼治疗慢性免疫性血小板减少症。
Blood. 2019 May 9;133(19):2027-2030. doi: 10.1182/blood-2018-11-852491. Epub 2019 Feb 25.
9
Long-term fostamatinib treatment of adults with immune thrombocytopenia during the phase 3 clinical trial program.在 3 期临床试验项目中，接受 fostamatinib 长期治疗的成人免疫性血小板减少症。
Am J Hematol. 2019 May;94(5):546-553. doi: 10.1002/ajh.25444. Epub 2019 Mar 13.
10
Trial protocol: a multicentre randomised trial of first-line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The FLIGHT trial.试验方案：一项针对新诊断免疫性血小板减少症一线治疗途径的多中心随机试验：标准类固醇治疗与类固醇联合霉酚酸酯治疗。FLIGHT试验。
BMJ Open. 2018 Oct 18;8(10):e024427. doi: 10.1136/bmjopen-2018-024427.