在1例新冠病毒疫苗接种后严重难治性免疫性血小板减少症患者中，霉酚酸酯联合罗米司亭治疗反应迅速
Rapid response to mycophenolate mofetil in combination with romiplostim in a case of severe refractory immune thrombocytopenia post COVID-19 vaccination.
作者信息
Nutalapati Snigdha, Gupta Garima, Hildebrandt Gerhard C
机构信息
Division of Hematology and Oncology University of Kentucky College of Medicine Lexington Kentucky USA.
出版信息
Clin Case Rep. 2021 Nov 6;9(11):e05035. doi: 10.1002/ccr3.5035. eCollection 2021 Nov.
Abstract
Vaccine mediated immune mediated thrombocytopenia (ITP) is exceedingly rare. We present a case of a young female who developed severe refractory ITP with multiple bleeding sites post second dose of COVID-19 vaccination. She was treated with a combination of romiplostim and mycophenolate mofetil that resulted in rapid platelet count recovery.
摘要
疫苗介导的免疫性血小板减少症（ITP）极为罕见。我们报告一例年轻女性病例，该患者在接种第二剂新冠疫苗后出现严重难治性ITP，并伴有多处出血部位。她接受了罗米司亭和霉酚酸酯联合治疗，血小板计数迅速恢复。
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本文引用的文献
1
Immune thrombocytopenia following COVID-19 mRNA vaccine: casuality or causality?
Intern Emerg Med. 2022 Jan;17(1):295-297. doi: 10.1007/s11739-021-02778-w. Epub 2021 Jun 7.
2
Secondary immune thrombocytopenia supposedly attributable to COVID-19 vaccination.
BMJ Case Rep. 2021 May 31;14(5):e242220. doi: 10.1136/bcr-2021-242220.
3
Thrombocytopenia following Pfizer and Moderna SARS-CoV-2 vaccination.
Am J Hematol. 2021 May 1;96(5):534-537. doi: 10.1002/ajh.26132. Epub 2021 Mar 9.
4
Immune thrombocytopenia in a 22-year-old post Covid-19 vaccine.
Am J Hematol. 2021 May 1;96(5):E133-E134. doi: 10.1002/ajh.26106. Epub 2021 Feb 11.
5
Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates.
N Engl J Med. 2020 Dec 17;383(25):2439-2450. doi: 10.1056/NEJMoa2027906. Epub 2020 Oct 14.
6
The Impact of the Microbiome on Immunity to Vaccination in Humans.
Cell Host Microbe. 2020 Aug 12;28(2):169-179. doi: 10.1016/j.chom.2020.06.014.
7
Combination of thrombopoietin receptor agonists, immunosuppressants and intravenous immunoglobulin as treatment of severe refractory immune thrombocytopenia in adults and children.
Br J Haematol. 2020 Apr;189(2):e37-e40. doi: 10.1111/bjh.16426. Epub 2020 Feb 24.
8
Fostamatinib for the treatment of chronic immune thrombocytopenia.
Blood. 2019 May 9;133(19):2027-2030. doi: 10.1182/blood-2018-11-852491. Epub 2019 Feb 25.
9
Long-term fostamatinib treatment of adults with immune thrombocytopenia during the phase 3 clinical trial program.
Am J Hematol. 2019 May;94(5):546-553. doi: 10.1002/ajh.25444. Epub 2019 Mar 13.
10
Trial protocol: a multicentre randomised trial of first-line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The FLIGHT trial.
BMJ Open. 2018 Oct 18;8(10):e024427. doi: 10.1136/bmjopen-2018-024427.
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