Ishii Arata, Tsukamoto Shokichi, Mishina Tatsuzo, Izumi Shintaro, Nagai Yurie, Yamazaki Miki, Hino Yutaro, Kayamori Kensuke, Oshima-Hasegawa Nagisa, Muto Tomoya, Mitsukawa Shio, Takeda Yusuke, Mimura Naoya, Ohwada Chikako, Nakaseko Chiaki, Ikeda Jun-Ichiro, Sakaida Emiko
Department of Hematology, Chiba University Hospital, Chiba, Japan.
Blood and Marrow Transplant Center, Chiba University Hospital, Chiba, Japan.
Leuk Res Rep. 2021 Oct 29;16:100278. doi: 10.1016/j.lrr.2021.100278. eCollection 2021.
A 45-year-old woman was diagnosed with myelodysplastic syndrome (MDS) with trisomy 8 and Behçet-like disease (BLD) with multiple colorectal ulcers. Nonspecific inflammatory cells were infiltrated in the intestinal mucosa, whereas fluorescence in situ hybridization (FISH) analysis revealed only sporadic trisomy 8-positive cells. She presented massive lower gastrointestinal bleeding early after bone marrow transplantation but achieved long-term remission of both MDS and BLD. This is the first report of massive gastrointestinal bleeding after transplantation for MDS with BLD. Based on FISH analysis, dysregulation of systemic inflammation may be involved in BLD rather than direct invasion by trisomy 8-positive MDS clones.
一名45岁女性被诊断为患有8号染色体三体的骨髓增生异常综合征（MDS）以及伴有多个结肠直肠溃疡的白塞氏病样疾病（BLD）。非特异性炎性细胞浸润于肠黏膜，而荧光原位杂交（FISH）分析仅发现散在的8号染色体三体阳性细胞。她在骨髓移植后早期出现大量下消化道出血，但MDS和BLD均实现了长期缓解。这是首例关于伴有BLD的MDS移植后发生大量胃肠道出血的报告。基于FISH分析，全身炎症失调可能与BLD有关，而非8号染色体三体阳性的MDS克隆直接侵袭所致。
