Tanaka M, Ono H, Kadoma Y, Imai Y
J Dent Res. 1987 Oct;66(10):1591-3. doi: 10.1177/00220345870660101601.
Fluoride incorporation into human enamel from an experimental sealant resin in vivo was investigated. The sealant consisted of a newly synthesized methacryloyl fluoride-methyl methacrylate (MF-MMA) copolymer resin, which contains acidic fluoride covalently bonded to carbonyl groups and releases fluoride ions slowly by hydrolysis in an aqueous environment. This experimental sealant was applied to the enamel of permanent pre-molars and the control sealant without MF-MMA copolymer to that of the contralateral teeth. Fluoride concentration was determined by an enamel biopsy procedure with acid-etching four weeks after the sealant application. As much as 3500 ppm fluoride was found to be deposited at 10 microns depth in the enamel under the MF-MMA copolymer sealant. The increase in fluoride concentration was significant even at 60 microns. Of the fluoride incorporated into the enamel, from 70 to 80% was present as a tightly bound form. This resin sealant is expected to protect the enamel from caries attack even after detachment of the sealant.
研究了一种实验性封闭剂树脂在体内使氟化物掺入人牙釉质的情况。该封闭剂由一种新合成的甲基丙烯酰氟-甲基丙烯酸甲酯（MF-MMA）共聚物树脂组成，其含有与羰基共价键合的酸性氟化物，并在水环境中通过水解缓慢释放氟离子。将这种实验性封闭剂应用于恒牙前磨牙的牙釉质，而将不含MF-MMA共聚物的对照封闭剂应用于对侧牙齿的牙釉质。在封闭剂应用四周后，通过酸蚀牙釉质活检程序测定氟化物浓度。发现在MF-MMA共聚物封闭剂下方的牙釉质中，在10微米深度处沉积了高达3500 ppm的氟化物。即使在60微米处，氟化物浓度的增加也很显著。掺入牙釉质的氟化物中，70%至80%以紧密结合的形式存在。预计这种树脂封闭剂即使在封闭剂脱落之后也能保护牙釉质免受龋齿侵袭。
