Chen Zhenzhen, Yan Youyou, Qi Chao, Liu Jia, Li Longbo, Wang Junnan
Department of Cardiology, Second Hospital of Jilin University, Changchun, China.
Front Cardiovasc Med. 2021 Oct 26;8:733229. doi: 10.3389/fcvm.2021.733229. eCollection 2021.
Cardiovascular diseases (CVDs) are the leading cause of deaths worldwide with regulated cell death playing an important role in cardiac pathophysiology. However, the classical mode of cell death cannot fully explain the occurrence and development of heart disease. In recent years, much research has been performed on ferroptosis, a new type of cell death that causes cell damage and contributes to the development of atherosclerosis, myocardial infarction, heart failure, and other diseases. In this review, we discuss the role of different organelles in ferroptosis and also focus on the relationship between autophagy and ferroptosis. Additionally, we describe the specific mechanism by which ferroptosis contributes to the development of CVD. Finally, we summarize the current research on ferroptosis-related pathway inhibitors and the applications of clinically beneficial cardiovascular drugs.
心血管疾病（CVDs）是全球主要死因，调节性细胞死亡在心脏病理生理学中起重要作用。然而，经典的细胞死亡模式无法完全解释心脏病的发生和发展。近年来，人们对铁死亡进行了大量研究，铁死亡是一种新型细胞死亡，可导致细胞损伤，并促进动脉粥样硬化、心肌梗死、心力衰竭等疾病的发展。在本综述中，我们讨论了不同细胞器在铁死亡中的作用，并聚焦于自噬与铁死亡之间的关系。此外，我们描述了铁死亡促进心血管疾病发展的具体机制。最后，我们总结了目前关于铁死亡相关途径抑制剂的研究以及临床有益心血管药物的应用。
