College of Chemistry & Environmental Science, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China.
Key Laboratory of Medicinal Chemistry, and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China.
Chem Commun (Camb). 2021 Nov 25;57(94):12655-12658. doi: 10.1039/d1cc04854f.
A practical electrophilic aminoselenation of -homoallyl benzimidate with diselenides promoted by PhICl/CuO has been developed. The easily available and stable diselenides were used as selenium sources. Various selenyl 1,3-oxazines, which are important frameworks in medicinal and biological chemistry, were easily obtained in moderate to good yields for the first time. Easy scaleup and scalability make this method attractive for the preparation of other valuable organoselenides.
PhICl/CuO 促进的 -高烯丙基苯并咪唑与二硒醚的实用亲电氨基硒化反应已经开发出来。该反应使用易得且稳定的二硒醚作为硒源。首次以中等至良好的产率轻松获得了各种硒代 1,3-恶嗪，它们是药物和生物化学中重要的骨架。该方法易于放大和扩展，对于制备其他有价值的有机硒化物具有吸引力。
