College of Chemistry & Environmental Science, Key Laboratory of Medicinal Chemistry, and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, Hebei University, 180 Wusi Donglu, Baoding 071002, P. R. China.
J Org Chem. 2023 Mar 3;88(5):3035-3045. doi: 10.1021/acs.joc.2c02729. Epub 2023 Feb 9.
We present a facile switchable regioselective 7- or 6- iodocyclization of -homoallyl benzimidates here, which affords various iodo-substituted 1,3-oxazines and tetrahydro-1,3-oxazepines in a controllable manner. The products can further undergo substitution reactions to afford a series of rich functionalized target heterocyclic molecules. The developed protocol has the advantages of mild conditions, simple operation, and excellent functional group compatibility.
我们在此提出了一种简便的可切换的区域选择性 7-或 6-碘环化-α-高烯丙基苯并咪唑，可可控地得到各种碘取代的 1,3-噁嗪和四氢-1,3-噁嗪。这些产物可以进一步进行取代反应，得到一系列丰富的功能化目标杂环分子。所开发的方案具有条件温和、操作简单和良好的官能团兼容性等优点。
