Tian Rui, Jiang Yujuan, Zhang Yanchun, Yan Xinyue, Zhou Yingwen, Chen Deqiang
Department of Rehabilitation, Cangzhou Central Hospital, Cangzhou, 061000, Hebei Province, China.
Department of Magnetic Resonance, Cangzhou Central Hospital, Cangzhou, 061000, Hebei Province, China.
Aging Clin Exp Res. 2022 May;34(5):997-1005. doi: 10.1007/s40520-021-02015-6. Epub 2021 Nov 12.
Mild cognitive impairment (MCI) is a clinical syndrome of mild memory or other cognitive impairment without dementia and is a clinical transition state between normal aging and dementia. Careful and meticulous nursing intervention can improve the clinical symptoms of MCI and delay the progression of the disease.
This research aimed to evaluate the efficacy of cognitive function training interventions in elderly patients with MCI.
106 patients were randomized into the intervention group or the control group. They received conventional nursing intervention and those in the intervention group received additional cognitive training program for 6 weeks. The Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), activities of daily living (ADL) scales, and Barthel index (BI) were evaluated before and 6 weeks after the intervention, as well as the serum levels of S100β and neuron-specific enolase (NSE) at two time points.
After intervention, the MMSE scores and MoCA scores in both groups were significantly increased and the score in the intervention group was significantly higher. In the intervention group, the performance of conventional nursing intervention and cognitive training program significantly increased the scores of ADL and BI (p < 0.001). The serum levels of NSE and S100β in the intervention group were significantly lower.
The performance of cognitive training program alleviated the brain tissue damage in elderly patients with MCI.
The performance of cognitive training program in elderly patients with MCI improved their cognitive ability and daily living ability.
轻度认知障碍（MCI）是一种无痴呆的轻度记忆或其他认知障碍的临床综合征，是正常衰老与痴呆之间的临床过渡状态。细致入微的护理干预可改善MCI的临床症状并延缓疾病进展。
本研究旨在评估认知功能训练干预对老年MCI患者的疗效。
106例患者随机分为干预组和对照组。对照组接受常规护理干预，干预组在常规护理干预基础上接受为期6周的认知训练项目。在干预前及干预6周后评估简易精神状态检查表（MMSE）、蒙特利尔认知评估量表（MoCA）、日常生活活动能力（ADL）量表及巴氏指数（BI），并在两个时间点检测血清S100β和神经元特异性烯醇化酶（NSE）水平。
干预后，两组的MMSE评分和MoCA评分均显著提高，且干预组评分更高。在干预组，常规护理干预与认知训练项目显著提高了ADL和BI评分（p < 0.001）。干预组的血清NSE和S100β水平显著降低。
认知训练项目改善了老年MCI患者的脑组织损伤。
认知训练项目改善了老年MCI患者的认知能力和日常生活能力。
