Wong P, Takabayashi K, Sugiura Y, Asai T, Itoh K, Yoshida S, Horie H
Jpn J Med. 1987 May;26(2):234-6. doi: 10.2169/internalmedicine1962.26.234.
A 43-year-old man with pancytopenia and circulating blast cells was found to have acute megakaryoblastic leukemia. Bone marrow biopsy disclosed reticulin fibrosis with infiltration of blast cells. Cytogenic study showed 48,XY,+15,+18. The megakaryocytic origin of blast cells was confirmed by platelet peroxidase reaction at ultrastructural level. The spleen which had not been felt on admission increased in size rapidly and ruptured abruptly. This appears to be the first reported case of a splenic rupture associated with acute megakaryoblastic leukemia.
一名43岁全血细胞减少且外周血出现原始细胞的男性被诊断为急性巨核细胞白血病。骨髓活检显示有网硬蛋白纤维化伴原始细胞浸润。细胞遗传学研究显示核型为48,XY,+15,+18。原始细胞的巨核细胞起源在超微结构水平通过血小板过氧化物酶反应得以证实。入院时未触及的脾脏迅速增大并突然破裂。这似乎是首例报道的与急性巨核细胞白血病相关的脾破裂病例。
