LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
CQM-Centro de Química da Madeira, Campus da Penteada, Universidade da Madeira, 9020-105 Funchal, Portugal.
Int J Mol Sci. 2021 Oct 28;22(21):11654. doi: 10.3390/ijms222111654.
The blood-brain barrier (BBB) is a barrier that separates the blood from the brain tissue and possesses unique characteristics that make the delivery of drugs to the brain a great challenge. To achieve this purpose, it is necessary to design strategies to allow BBB passage, in order to reach the brain and target the desired anatomic region. The use of nanomedicine has great potential to overcome this problem, since one can modify nanoparticles with strategic molecules that can interact with the BBB and induce uptake through the brain endothelial cells and consequently reach the brain tissue. This review addresses the potential of nanomedicines to treat neurological diseases by using nanoparticles specially developed to cross the BBB.
血脑屏障（BBB）是一种将血液与脑组织分隔开的屏障，具有独特的特性，使得将药物递送到大脑成为一项巨大的挑战。为了实现这一目的，有必要设计允许 BBB 穿透的策略，以便到达大脑并靶向所需的解剖区域。纳米医学的应用具有克服这一问题的巨大潜力，因为可以用可以与 BBB 相互作用并诱导脑内皮细胞摄取的策略分子来修饰纳米颗粒，从而到达脑组织。本文综述了专门开发用于穿透 BBB 的纳米颗粒来治疗神经疾病的纳米药物的潜力。
