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表面修饰环肽 cRGD 的氧化铁纳米颗粒用于脑肿瘤的磁共振成像。

Iron oxide nanoparticle surface decorated with cRGD peptides for magnetic resonance imaging of brain tumors.

机构信息

Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057, CNRS and Université Paris Diderot, 75205 Paris Cedex 05, France.

Unité d'Imagerie par Résonance Magnétique et de Spectroscopie, CEA/DRF/I2BM/NeuroSpin, F-91191, Gif-sur-Yvette, France.

出版信息

Biochim Biophys Acta Gen Subj. 2017 Jun;1861(6):1515-1520. doi: 10.1016/j.bbagen.2016.12.020. Epub 2016 Dec 23.

DOI:10.1016/j.bbagen.2016.12.020
PMID:28017683
Abstract

In this article, a specific targeting Magnetic Resonance Imaging (MRI) nanoplatform, composed by iron oxide nanoparticle (NP) with cRGD peptides as targeting agent onto NP surface, is explored for the diagnosis of brain tumors by MRI using intracranial U87MG mice xenograft tumor. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editor: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.

摘要

本文探索了一种特定的靶向磁共振成像（MRI）纳米平台，该平台由氧化铁纳米颗粒（NP）与靶向剂 cRGD 肽组成，用于通过颅内 U87MG 小鼠异种移植瘤进行 MRI 诊断脑肿瘤。本文是题为“生物纳米材料的最新进展”特刊的一部分，客座编辑为 Marie-Louise Saboungi 博士和 Samuel D. Bader 博士。

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