Dharmasena F, Englert H, Catovsky D, Galton D A, Drysdale H C
Postgrad Med J. 1986 Nov;62(733):1045-6. doi: 10.1136/pgmj.62.733.1045.
Reiter's syndrome and other reactive arthritides have been described following infection with various organisms although they can occur in unusual circumstances without an obvious infectious precipitant. We have recently witnessed two attacks of reactive arthritis and keratoderma blenorrhagica occurring in an HLA B27 adult male following chemotherapy on two separate occasions with the same drugs for acute myeloid leukaemia. No attacks occurred before or following the cessation of these drugs. This supports the view that in Reiter's syndrome a common pathogenic pathway is triggered by an 'arthritogenic factor' which in this case appears to have been chemical.
赖特综合征和其他反应性关节炎在感染各种病原体后已有报道，尽管它们可在无明显感染诱因的异常情况下发生。我们最近目睹了一名 HLA B27 成年男性在两次分别使用相同药物治疗急性髓系白血病的化疗后，出现了两次反应性关节炎和脓性皮肤角化病发作。在这些药物使用之前或停用之后均未发作。这支持了一种观点，即在赖特综合征中，一条常见的致病途径是由一种“致关节炎因子”触发的，在这种情况下该因子似乎是化学物质。
