分子方法对抗无义突变。
Molecular Approaches Fighting Nonsense.
机构信息
Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche-STEBICEF, Università degli Studi di Palermo, V.le delle Scienze Ed. 17, 90128 Palermo, Italy.
出版信息
Int J Mol Sci. 2021 Nov 3;22(21):11933. doi: 10.3390/ijms222111933.
Abstract
Nonsense mutations are the result of single nucleotide substitutions in the DNA that change a sense codon (coding for an amino acid) to a nonsense or premature termination codon (PTC) within the coding region of the mRNA [...].
摘要
无义突变是 DNA 中单核苷酸替换的结果，它会将一个有意义的密码子（编码一种氨基酸）改变为编码区 mRNA 中的无义或过早终止密码子（PTC）[...]。
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