Petersen H, Løge I, Johannessen T, Fjøsne U, Kleveland P M, Kristensen P, Sandbakken P, Hafstad P E, Halvorsen T
Scand J Gastroenterol Suppl. 1987;128:108-13. doi: 10.3109/00365528709090977.
Non-ulcer dyspepsia (NUD) is a poorly defined heterogenous condition less well suited for the conventional randomized and placebo controlled parallel type trials. We have designed a multi cross-over model (MCO-model) with the facility of providing information about drug responses in individual patients. A pilot study suggested that the model may identify individual cimetidine responders among patients with dyspepsia. Preliminary findings from an ongoing study in patients with NUD supports the existence of a subgroup of cimetidine responders characterized by gastroesophageal reflux symptoms and possibly an increased basal acid secretion.
非溃疡性消化不良（NUD）是一种定义不明确的异质性疾病，不太适合传统的随机和安慰剂对照平行试验类型。我们设计了一种多交叉模型（MCO模型），该模型能够提供个体患者药物反应的信息。一项试点研究表明，该模型可能识别出消化不良患者中对西咪替丁有反应的个体。正在进行的一项针对NUD患者的研究的初步结果支持存在一个以西咪替丁反应者为特征的亚组，其特点是有胃食管反流症状，且基础胃酸分泌可能增加。
