Department of Kinesiology, University of Rhode Island, Kingston, RI, USA.
Department of Biomedical Sciences, Quinnipiac University, Hamden, CT, USA.
J Hum Hypertens. 2014 May;28(5):303-9. doi: 10.1038/jhh.2013.109. Epub 2013 Oct 31.
Prehypertension is associated with reduced conduit artery endothelial function and perturbation of oxidant/antioxidant status. It is unknown whether endothelial dysfunction persists to resistance arteries and whether exercise training affects oxidant/antioxidant balance in young prehypertensives. We examined resistance artery function using venous occlusion plethysmography measurement of forearm (FBF) and calf blood flow (CBF) at rest and during reactive hyperaemia (RH), as well as lipid peroxidation (8-iso-PGF2α) and antioxidant capacity (Trolox-equivalent antioxidant capacity; TEAC) before and after exercise intervention or time control. Forty-three unmedicated prehypertensive and 15 matched normotensive time controls met screening requirements and participated in the study (age: 21.1±0.8 years). Prehypertensive subjects were randomly assigned to resistance exercise training (PHRT; n=15), endurance exercise training (PHET; n=13) or time-control groups (PHTC; n=15). Treatment groups exercised 3 days per week for 8 weeks. Peak and total FBF were lower in prehypertensives than normotensives (12.7±1.2 ml min(-1) per100 ml tissue and 89.1±7.7 ml min(-1) per 100 ml tissue vs 16.3±1.0 ml min(-1) per 100 ml tissue and 123.3±6.4 ml min(-1) per 100 ml tissue, respectively; P<0.05). Peak and total CBF were lower in prehypertensives than normotensives (15.3±1.2 ml min(-1) per 100 ml tissue and 74±8.3 ml min(-1) per 100 ml tissue vs 20.9±1.4 ml min(-1) per 100 ml tissue and 107±9.2 ml min(-1) per 100 ml tissue, respectively; P<0.05). PHRT and PHET improved humoral measures of TEAC (+24 and +30%) and 8-iso-PGF2α (-43 and -40%, respectively; P < or = 0.05). This study provides evidence that young prehypertensives exhibit reduced resistance artery endothelial function and that short-term (8 weeks) resistance or endurance training are effective in improving resistance artery endothelial function and oxidant/antioxidant balance in young prehypertensives.
高血压前期与大血管内皮功能障碍和氧化应激/抗氧化失衡有关。目前尚不清楚高血压前期患者的内皮功能是否持续存在于阻力血管，以及运动训练是否会影响年轻高血压前期患者的氧化应激/抗氧化平衡。我们通过前臂（FBF）和小腿血流（CBF）的静脉闭塞体积描记法测量，在静息和反应性充血（RH）期间，以及运动干预或时间对照前后的脂质过氧化（8-iso-PGF2α）和抗氧化能力（Trolox 等效抗氧化能力；TEAC），检查了阻力血管的功能。43 名未经药物治疗的高血压前期患者和 15 名匹配的正常血压时间对照组符合筛选要求并参与了研究（年龄：21.1±0.8 岁）。高血压前期患者被随机分配到阻力运动训练（PHRT；n=15）、耐力运动训练（PHET；n=13）或时间对照组（PHTC；n=15）。治疗组每周运动 3 天，共 8 周。高血压前期患者的峰值和总 FBF 均低于正常血压者（12.7±1.2 ml/min/100 ml 组织和 89.1±7.7 ml/min/100 ml 组织，分别为 16.3±1.0 ml/min/100 ml 组织和 123.3±6.4 ml/min/100 ml 组织；P<0.05）。高血压前期患者的峰值和总 CBF 均低于正常血压者（15.3±1.2 ml/min/100 ml 组织和 74±8.3 ml/min/100 ml 组织，分别为 20.9±1.4 ml/min/100 ml 组织和 107±9.2 ml/min/100 ml 组织；P<0.05）。PHRT 和 PHET 改善了 TEAC（+24%和+30%）和 8-iso-PGF2α（-43%和-40%，分别；P <或= 0.05）的体液测量值。本研究表明，年轻的高血压前期患者表现出阻力血管内皮功能障碍，短期（8 周）的阻力或耐力训练可有效改善年轻高血压前期患者的阻力血管内皮功能和氧化应激/抗氧化平衡。
