Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya st., 16/10, 117997 Moscow, Russia.
Hematology Department, Sechenov First Moscow State Medical University, Russian MOH, Moscow 8-2 Trubetskaya str., 119991 Moscow, Russia.
Molecules. 2021 Oct 29;26(21):6550. doi: 10.3390/molecules26216550.
The paper summarizes the available information concerning the biological properties and biomedical applications of Thymodepressin. This synthetic peptide drug displays pronounced immunoinhibitory activity across a wide range of conditions in vitro and in vivo. The history of its unforeseen discovery is briefly reviewed, and the current as well as potential expansion areas of medicinal practice are outlined. Additional experimental evidence is obtained, demonstrating several potential advantages of Thymodepressin over another actively used immunosuppressor drug, cyclosporin A.
本文总结了有关胸腺降钙素的生物学特性和生物医学应用的现有信息。这种合成肽药物在体外和体内的多种情况下均显示出明显的免疫抑制活性。简要回顾了其意外发现的历史，并概述了当前和潜在的医学实践扩展领域。获得了额外的实验证据，证明胸腺降钙素相对于另一种广泛使用的免疫抑制剂药物环孢素 A 具有若干潜在优势。
