具有分化活性的骨髓肽的合成与性质
[Synthesis and properties of the myelopeptides with differentiating activity].
作者信息
Fonina L A, Kudriavtseva E V, Bespalova Zh D, Efremov M A, Mikhaĭlova A A, Kirilina E A
出版信息
Bioorg Khim. 2010 Jul-Aug;36(4):493-7. doi: 10.1134/s1068162010040035.
PMID:20823917
Abstract
The bone marrow myelopeptides Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro (MP-4) and Val-Asp-Pro-Pro (MP-6) have been synthesised by a classical method and by a solid phase synthesis. The differentiating activity of MP-4 and MP-6 in human leukemia cells HL-60 and K-562 has been studied. Both peptides induce terminal differentiation of these cell lines but the mechanism of action of peptides MP-4 and MP-6 is distinguished.
摘要
骨髓髓肽苯丙氨酸-精氨酸-脯氨酸-精氨酸-异亮氨酸-蛋氨酸-苏氨酸-脯氨酸（MP-4）和缬氨酸-天冬氨酸-脯氨酸-脯氨酸（MP-6）已通过经典方法和固相合成法合成。对MP-4和MP-6在人白血病细胞HL-60和K-562中的分化活性进行了研究。两种肽均诱导这些细胞系的终末分化，但MP-4和MP-6肽的作用机制有所不同。
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