Horsman D E, Kalousek D K
Am J Hematol. 1987 Sep;26(1):77-82. doi: 10.1002/ajh.2830260109.
Two patients with acute myelomonocytic leukemia (AML-M4) and a specific chromosomal translocation t(6;9)(p23;q34) are reported and compared to 21 AML patients with the same translocation collected from the literature. Our observation suggest that AML with t(6;9)(p23;q34) is characterized by myelodysplasia, basophilia, and a variety of blast cell morphologies (M1, M2, M4) with a greater proportion of the cases than previously appreciated being examples of acute myelomonocytic leukemia (AML-M4). The consistent association of myelodysplasia provokes the proposal that this subtype of de novo AML is a result of an acute stem cell disorder. The poor outcome with standard AML chemotherapy experienced in this group of relatively young patients necessitates consideration of alternative therapeutic strategies such as early bone marrow transplantation.
本文报告了两名患有急性粒单核细胞白血病（AML-M4）并伴有特异性染色体易位t(6;9)(p23;q34)的患者，并与从文献中收集的另外21名具有相同易位的AML患者进行了比较。我们的观察结果表明，伴有t(6;9)(p23;q34)的AML具有骨髓发育异常、嗜碱性粒细胞增多以及多种原始细胞形态（M1、M2、M4）的特征，其中急性粒单核细胞白血病（AML-M4）的病例比例高于以往认识。骨髓发育异常的持续关联促使人们提出，这种原发性AML亚型是急性干细胞疾病的结果。这组相对年轻的患者在接受标准AML化疗时预后较差，因此有必要考虑如早期骨髓移植等替代治疗策略。
