Lillington D M, MacCallum P K, Lister T A, Gibbons B
ICRF Department of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London, UK.
Leukemia. 1993 Apr;7(4):527-31.
The clinical, hematological, and cytogenetic data from two young adults with acute myeloid leukemia (AML) FAB type M1 is described. At diagnosis, cytogenetic investigation revealed the presence of the translocation t(6;9)(p23;q34). Bone marrow basophilia was not detected in either patient nor was there any evidence of preceding or underlying myelodysplasia. Both patients achieved complete remission (CR) and one patient remains in CR of over 5 years duration. It is suggested that the presence of basophilia may be associated with the myelodysplasia rather than the chromosome anomaly t(6;9).
描述了两名急性髓系白血病（AML）FAB M1型年轻成人的临床、血液学和细胞遗传学数据。诊断时，细胞遗传学检查发现存在t(6;9)(p23;q34)易位。两名患者均未检测到骨髓嗜碱性粒细胞增多，也没有任何先前或潜在骨髓发育异常的证据。两名患者均实现完全缓解（CR），其中一名患者持续CR超过5年。提示嗜碱性粒细胞增多可能与骨髓发育异常有关，而非与染色体异常t(6;9)有关。
