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DSLINK：一种用于对有三体后代的家庭进行基因-着丝粒连锁分析的计算机程序。

DSLINK: a computer program for gene-centromere linkage analysis in families with a trisomic offspring.

作者信息

Halloran S L, Chakravarti A

出版信息

Am J Hum Genet. 1987 Sep;41(3):350-5.

PMID:3477097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1684185/
Abstract

Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.

摘要

三体个体为基因 - 着丝粒作图提供了信息，因为减数分裂四分体中的四条染色单体中的两条能够被检测到。当有了着丝粒标记时，在有一个或多个三体后代的核心家庭中，可以进行着丝粒与任何标记位点之间的连锁分析。由于传统的连锁程序只考虑二体个体，我们编写了一个FORTRAN计算机程序DSLINK，它根据三体和二体后代的信息进行基因 - 着丝粒连锁分析。这个程序使得研究重组与染色体分离之间的关系成为可能。

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本文引用的文献

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The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity.胰岛素依赖型糖尿病（IDDM）异质性的研究：连锁研究、双基因座模型与遗传异质性
Am J Hum Genet. 1983 Nov;35(6):1139-55.
2
Multilocus recombination frequencies.多位点重组频率
Genet Res. 1984 Aug;44(1):99-107. doi: 10.1017/s0016672300026276.
3
Trisomy in man.人类的三体性
Annu Rev Genet. 1984;18:69-97. doi: 10.1146/annurev.ge.18.120184.000441.
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Tests of hypotheses on recombination frequencies.
Genet Res. 1985 Jun;45(3):279-86. doi: 10.1017/s0016672300022266.
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Estimating distances from the centromere by means of benign ovarian teratomas in man.借助人类良性卵巢畸胎瘤估算着丝粒的距离。
Ann Hum Genet. 1976 Nov;40(2):191-6. doi: 10.1111/j.1469-1809.1976.tb00179.x.
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A mapping function for man.人类的映射函数。
Hum Hered. 1977;27(2):99-104. doi: 10.1159/000152856.

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