Halloran S L, Chakravarti A
Am J Hum Genet. 1987 Sep;41(3):350-5.
Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.
三体个体为基因 - 着丝粒作图提供了信息，因为减数分裂四分体中的四条染色单体中的两条能够被检测到。当有了着丝粒标记时，在有一个或多个三体后代的核心家庭中，可以进行着丝粒与任何标记位点之间的连锁分析。由于传统的连锁程序只考虑二体个体，我们编写了一个FORTRAN计算机程序DSLINK，它根据三体和二体后代的信息进行基因 - 着丝粒连锁分析。这个程序使得研究重组与染色体分离之间的关系成为可能。
