对酵母中含有脂肪酸合成酶基因复合体（fas1）的染色体三体的杂交菌株进行遗传分析。
Genetic analysis of hybrid strains trisomic for the chromosome containing a fatty acid synthetase gene complex (fas1) in yeast.
作者信息
Culbertson M R, Henry S A
出版信息
Genetics. 1973 Nov;75(3):441-58. doi: 10.1093/genetics/75.3.441.
Abstract
Evidence of spontaneous n+1 aneuploidy has been obtained by trisomic segregation analysis of four independently maintained stocks of Saccharomyces cerevisiae defective in saturated fatty acid synthesis (fas1). In all cases tested, only the chromosome bearing the mutant fatty acid locus was disomic. Tetrad analysis of trisomic hybrids enabled the identification of chromosome XI as the one bearing the fatty acid locus and the assignment of fragment 5 to chromosome XI. Statistical analysis of tetrad frequencies generated by markers in triplex configuration provided information on the meiotic configuration of pairing of the three homologous chromosomes. The possible relationship between defective nuclear membranes and the disjunction of chromosomes in fas1 strains is discussed.
摘要
通过对酿酒酵母中四个独立保存的饱和脂肪酸合成缺陷型（fas1）菌株进行三体分离分析，获得了自发n + 1非整倍体的证据。在所有测试案例中，只有携带突变脂肪酸位点的染色体是二体的。三体杂种的四分体分析能够确定XI号染色体为携带脂肪酸位点的染色体，并将片段5定位到XI号染色体上。对三联体构型标记产生的四分体频率进行统计分析，提供了三条同源染色体配对的减数分裂构型信息。文中还讨论了fas1菌株中核膜缺陷与染色体分离之间的可能关系。
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