Chin Re-I, Schiff Joshua P, Brenneman Randall J, Gay Hiram A, Thorstad Wade L, Lin Alexander J
Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MI 63110, USA.
Cancers (Basel). 2021 Oct 20;13(21):5269. doi: 10.3390/cancers13215269.
Radiotherapy plays an important role in the definitive and adjuvant treatment of head and neck squamous cell carcinoma (HNSCC). However, standard courses of radiation therapy may contribute to the depletion of circulating lymphocytes and potentially attenuate optimal tumor antigen presentation that may be detrimental to the efficacy of novel immunotherapeutic agents. This review explores the advantages of restricting radiation to the primary tumor/tumor bed and ipsilateral elective neck as it pertains to the evolving field of immunotherapy.
放射治疗在头颈部鳞状细胞癌（HNSCC）的根治性和辅助治疗中发挥着重要作用。然而，标准的放射治疗疗程可能会导致循环淋巴细胞的耗竭，并可能削弱最佳肿瘤抗原呈递，这可能对新型免疫治疗药物的疗效产生不利影响。本综述探讨了将放射治疗局限于原发肿瘤/肿瘤床和同侧选择性颈部的优势，因为这与不断发展的免疫治疗领域相关。
Zotero 插件