转录因子组合起来绘制甲基化景观。

Transcription factors combine to paint the methylation landscape.

机构信息

Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Trends Immunol. 2021 Dec;42(12):1060-1062. doi: 10.1016/j.it.2021.10.011. Epub 2021 Nov 9.

DOI:10.1016/j.it.2021.10.011

PMID:34772620

Abstract

There is paucity of information about DNA methylation dynamics in immune cells. Roy et al. mapped the DNA methylation status of several thousand differentially methylated CpGs in human immune cells. They reported that the extent of cell type-specific hypermethylation is intriguingly most prevalent in adaptive immune cells rather than innate cells.

摘要

有关免疫细胞中 DNA 甲基化动态的信息很少。Roy 等人绘制了人类免疫细胞中数千个差异甲基化 CpG 的 DNA 甲基化状态。他们报告说，细胞类型特异性超甲基化的程度在适应性免疫细胞中而不是先天免疫细胞中最为普遍，这令人好奇。