Transplant Center, Clinica Alemana de Santiago-Universidad del Desarrollo, Santiago, Chile.
Department of Surgery, Universidad de Chile, Santiago, Chile.
Dev World Bioeth. 2022 Dec;22(4):259-266. doi: 10.1111/dewb.12338. Epub 2021 Nov 13.
Organ transplantation is a lifesaving procedure for end-organ damage and remains up to today as the most cost-effective alternative to treat these conditions. However, the main limitation to performing organ transplants is the availability of donor organs suitable for transplantation. To increase the donor pool, expanding organ donation from the conventional neurologic determination of death (NDD) to include circulatory determination of death (DCD) has been a well-established method of increasing donors in other countries. In this article, we discuss the clinical and ethical considerations for introducing DCD in Chile. The concepts we have used could very well be translatable to other similar countries which have not implemented this donation system yet. The most relevant issue to date is that DCD needs to alter the care of dying patients to obtain quality donor organs. In some countries, including Chile, there are some cultural barriers regarding withdrawal-of-care. These barriers include confusing withdrawal of care with acceleration of death, which leads to many practitioners refusing to remove artificial life support, and in turn only minimize ventilatory support or switch to a T-tube (without extubation). This cultural barrier could be overcome with careful consideration of the opinions of healthcare workers, family members, community and policy-based stakeholders. We also identified ethical issues related to informed consent of both donor and recipients, among other relevant ethical considerations. In conclusion, DCD donation in Chile can increase organ donation numbers in one of Latin America's countries with the lowest effective donor rate. However, this opportunity must be taken with caution to avoid the opposite effect if this policy is not well implemented, respecting the sound ethical principles mentioned in this paper.
器官移植是治疗终末期器官损伤的救命手段,迄今为止,它仍然是治疗这些疾病最具成本效益的替代方法。然而,进行器官移植的主要限制是缺乏适合移植的供体器官。为了增加供体器官数量,许多国家已经采用了一种将器官捐献从传统的脑死亡判定(NDD)扩大到循环死亡判定(DCD)的方法。在本文中,我们讨论了在智利引入 DCD 的临床和伦理考虑因素。我们所使用的概念在其他尚未实施这种捐赠制度的类似国家也可以很好地转化。迄今为止,最相关的问题是 DCD 需要改变临终患者的护理方式,以获得高质量的供体器官。在包括智利在内的一些国家,存在一些与放弃治疗有关的文化障碍。这些障碍包括将放弃治疗与加速死亡混淆,这导致许多医生拒绝去除人工生命支持,进而仅最小化通气支持或切换到 T 管(不拔管)。通过仔细考虑医护人员、家属、社区和基于政策的利益相关者的意见,可以克服这种文化障碍。我们还确定了与供体和受者知情同意相关的伦理问题,以及其他相关的伦理考虑因素。总之,在智利,DCD 捐赠可以增加拉丁美洲一个有效供体率最低的国家的器官捐赠数量。然而,如果这项政策实施不当,必须谨慎行事,以免适得其反,同时要尊重本文中提到的合理伦理原则。