Greek Aerospace Medical Association and Space Research (GASMA-SR), Ethnikis Antistasis 44, Kalamaria, 5513, Thessaloniki, Greece.
Biomedical Engineering and Aerospace Neuroscience (BEAN), Laboratory of Medical Physics, Medical School, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
High Blood Press Cardiovasc Prev. 2022 Jan;29(1):65-74. doi: 10.1007/s40292-021-00486-2. Epub 2021 Nov 13.
Experiments during spaceflight and simulated microgravity as head-down tilt bedrest, demonstrated the role of arterial stiffness among others, in microgravity induced cardiovascular pathologies and emphasized the need for a robust countermeasure.
The purpose of the present study was to evaluate the use of a new countermeasure, consisting of a high intensity Reactive Sledge (RSL) jumps training protocol, to counteract changes in arterial stiffness during long term head down tilt bedrest (LTBR).
The participants enrolled in the study were 23 male, healthy volunteers, aged between 20 and 45 years, subjected to LTBR for 60 days and randomly assigned either to a control (11) or to a training sledge (12) group using RSL 3-4 times per week, as a countermeasure. Recorded values were systolic and diastolic blood pressure, heart rate and the user's arterial stiffness index.
Compared to baseline measurements, there was a deterioration in the values of arterial stiffness, systolic and diastolic blood pressure and heart rate, in both groups until day 35 of LTBR, interpreted as adaptation to the microgravity environment. From this day until the end of the experiment, arterial stiffness of the control group was constantly fluctuating, while constantly improving for the training group. During the recovery period, arterial stiffness values returned to the pre-experimental levels in both groups.
Overall, arterial stiffness increased the longer the time spent in LTBR and the countermeasure was partially effective in preventing the observed phenomenon. German Clinical Trials Register (DRKS), DRKS00012946, September 18, 2017, retrospectively registered.
在太空飞行和模拟微重力条件下进行的实验，例如头低位卧床休息，证明了动脉僵硬等因素在微重力引起的心血管病变中的作用，并强调了需要采取强有力的对策。
本研究的目的是评估一种新对策的使用，该对策由高强度反应雪橇（RSL）跳跃训练方案组成，以抵消长期头低位卧床休息（LTBR）期间动脉僵硬的变化。
本研究招募了 23 名年龄在 20 至 45 岁之间的健康男性志愿者，他们接受了 60 天的 LTBR，并随机分为对照组（11 人）或训练雪橇组（12 人），每周使用 RSL 进行 3-4 次训练，作为对策。记录的数值包括收缩压和舒张压、心率和用户的动脉僵硬指数。
与基线测量值相比，两组的动脉僵硬、收缩压和舒张压以及心率值在 LTBR 的第 35 天之前都有所恶化，这被解释为对微重力环境的适应。从这一天到实验结束，对照组的动脉僵硬一直波动不定，而训练组则一直改善。在恢复期，两组的动脉僵硬值均恢复到实验前的水平。
总的来说，在 LTBR 中花费的时间越长，动脉僵硬就越高，对策在一定程度上有效预防了观察到的现象。德国临床试验注册处（DRKS），DRKS00012946，2017 年 9 月 18 日，回顾性注册。
