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成人囊性纤维化的非肺部并发症:成人囊性纤维化系列。

Emerging Nonpulmonary Complications for Adults With Cystic Fibrosis: Adult Cystic Fibrosis Series.

机构信息

Department of Medicine and the Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

Manchester Adult Cystic Fibrosis Centre, Manchester University NHS Foundation Trust, Manchester, England.

出版信息

Chest. 2022 May;161(5):1211-1224. doi: 10.1016/j.chest.2021.11.001. Epub 2021 Nov 10.

Abstract

Improved treatments for cystic fibrosis (CF)-related lung disease have resulted in increased longevity, but also increased prevalence and severity of extrapulmonary manifestations of CF, treatment-related complications, age-related conditions, and psychosocial effects of longstanding chronic disease. Likewise, the recognition of mild CF phenotypes has changed the landscape of CF disease. This review outlines our current understanding of the common extrapulmonary complications of CF, as well as the changing landscape and future directions of the extrapulmonary complications experienced by patients with CF.

摘要

囊性纤维化(CF)相关肺部疾病的治疗方法得到了改善,这导致患者的寿命延长,但也增加了 CF 的肺外表现、治疗相关并发症、与年龄相关的疾病以及长期慢性疾病的心理社会影响的发生率和严重程度。同样,对轻度 CF 表型的认识改变了 CF 疾病的格局。本文概述了我们目前对 CF 常见肺外并发症的认识,以及 CF 患者经历的肺外并发症的变化格局和未来方向。

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