Naskalski J W
Department of Biochemical Diagnostics, Medical Academy, Kraków, Poland.
Haematologia (Budap). 1987;20(2):89-99.
Elevated RNase activity which occurs in serum and urine of CGL patients parallels the urinary protein excretion. Acid RNase and alkaline RNase activities in urine of CGL patients, as well as acid and alkaline RNase clearance values correlated with the urinary protein concentration. Mean urinary protein level in CGL patients was approximately twice as high as that in controls. The molecular mass of CGL urinary proteins ranged from 12,000 to 80,000 proving the LMWP type of proteinuria. No particular protein contributed to the elevation of LMWPs in CGL urine. Among numerous protein fractions, albumin, acid alpha 1 glycoprotein, prealbumin RNase and in a few cases LZM were observed. The results of this study suggest that the increase of RNase activity in serum and urine reflects a more general phenomenon of increase in excretion of the entire set of LMWPs.
慢性粒细胞白血病（CGL）患者血清和尿液中出现的核糖核酸酶（RNase）活性升高与尿蛋白排泄平行。CGL患者尿液中的酸性RNase和碱性RNase活性，以及酸性和碱性RNase清除率值与尿蛋白浓度相关。CGL患者的平均尿蛋白水平约为对照组的两倍。CGL患者尿蛋白的分子量范围为12,000至80,000，证实为低分子量蛋白尿（LMWP）类型。CGL尿液中没有特定蛋白质导致LMWP升高。在众多蛋白质组分中，观察到白蛋白、酸性α1糖蛋白、前白蛋白RNase，少数情况下还观察到溶菌酶（LZM）。本研究结果表明，血清和尿液中RNase活性的增加反映了整个低分子量蛋白质（LMWP）排泄增加这一更为普遍的现象。
