Departman of Emergency Medicine, Mengucekgazi Education and Research Hospital, Erzincan, Turkey.
Departman of Emergency Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Am J Emerg Med. 2022 Jan;51:223-227. doi: 10.1016/j.ajem.2021.10.058. Epub 2021 Nov 3.
The absence of a specific biomarker for acute mesenteric ischemia diagnosis results in a delay in diagnosis and treatment, as well as a high mortality rate. The current research examined whether the proteins adropin, HIF-1α, and apelin may be used to help in the early detection of acute mesenteric ischemia.
A total of 20 patients with acute mesenteric ischemia, 20 patients with abdominal pain, and 20 healthy controls were included in the study. The levels of adropin, HIF-1, and apelin in the serum were determined using the ELISA method.
Adropin concentrations were significantly higher in the acute mesenteric ischemia group than in the abdominal pain and healthy control groups (p < 0.05). HIF-1α levels were considerably greater in patients with acute mesenteric ischemia compared to both the abdominal pain group and the healthy control group (p < 0.05). There was no difference in apelin levels between the acute mesenteric ischemia and abdominal pain groups (p > 0.05). HIF-1α was found to be moderate (AUC: 0.705) and adropin was found to be a weak biomarker (AUC: 0.692) in the ROC analysis for acute mesenteric ischemia.
In this study of 20 patients with acute mesenteric ischemia, we found adropin and HIF-1α levels to be increased compared to patients with abdominal pain who did not have acute mesenteric ischemia.
急性肠系膜缺血诊断缺乏特异性生物标志物，导致诊断和治疗延误，死亡率高。本研究探讨了降钙素原、HIF-1α和apelin 蛋白是否可用于帮助早期诊断急性肠系膜缺血。
本研究共纳入 20 例急性肠系膜缺血患者、20 例腹痛患者和 20 例健康对照者。采用 ELISA 法测定血清降钙素原、HIF-1α和 apelin 水平。
急性肠系膜缺血组降钙素原浓度明显高于腹痛组和健康对照组（p<0.05）。急性肠系膜缺血患者 HIF-1α 水平明显高于腹痛组和健康对照组（p<0.05）。急性肠系膜缺血组和腹痛组 apelin 水平无差异（p>0.05）。ROC 分析显示，HIF-1α 对急性肠系膜缺血具有中等诊断价值（AUC：0.705），降钙素原具有弱诊断价值（AUC：0.692）。
本研究纳入 20 例急性肠系膜缺血患者，发现与无急性肠系膜缺血的腹痛患者相比，降钙素原和 HIF-1α 水平升高。
