Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shan Xi, China.
Department of Pediatrics, The First People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai, China.
Pediatr Diabetes. 2020 Nov;21(7):1132-1139. doi: 10.1111/pedi.13101. Epub 2020 Aug 27.
Metabolic syndrome (MetS) is the most common condition associated with childhood and adolescent obesity and is a challenging public health issue. Very few studies have described the specificity and sensitivity of serum levels of adropin and apelin-12 as predictors of MetS. The aim of this study was to evaluate the association between serum levels of adropin and apelin-12 and MetS, and their sensitivity as predictors of MetS in obese children.
This study involved 138 children. The study group included obese subjects with MetS, and the two control groups included obese subjects without MetS and normal weight subjects. Anthropometric parameters and clinical data were collected. Plasma levels of apelin-12, adropin, leptin, adiponectin, and TNF-α were also measured.
Obese children with MetS had significantly higher levels of apelin-12 and significantly lower levels of adropin when compared with those in children without MetS. In logistic regressions, we identified that apelin-12 was a risk factor for metabolic syndrome, and adropin was a protecting factor of having MetS after adjusting for age, sex, and puberty. Furthermore, ROC analysis revealed that adropin and apelin-12 are more sensitive predictors of metabolic syndrome than leptin and adiponectin.
Serum adropin and apelin-12 levels can be useful biomarkers for predicting MetS in obese children. Our findings could provide a novel approach for the treatment and prevention of MetS.
代谢综合征（MetS）是与儿童和青少年肥胖最相关的最常见病症，也是一个具有挑战性的公共卫生问题。很少有研究描述过作为 MetS 预测因子的血清 adropin 和 apelin-12 水平的特异性和敏感性。本研究旨在评估血清 adropin 和 apelin-12 水平与 MetS 的相关性，以及它们作为肥胖儿童 MetS 预测因子的敏感性。
本研究共纳入 138 名儿童。研究组纳入患有 MetS 的肥胖儿童，两组对照组分别纳入无 MetS 的肥胖儿童和体重正常的儿童。收集了人体测量参数和临床数据。还测量了血浆 apelin-12、adropin、瘦素、脂联素和 TNF-α水平。
与无 MetS 的肥胖儿童相比，患有 MetS 的肥胖儿童的 apelin-12 水平显著升高，adropin 水平显著降低。在逻辑回归中，我们发现调整年龄、性别和青春期后，apelin-12 是代谢综合征的危险因素，而 adropin 是患有 MetS 的保护因素。此外，ROC 分析显示，adropin 和 apelin-12 是预测代谢综合征比瘦素和脂联素更敏感的标志物。
血清 adropin 和 apelin-12 水平可作为肥胖儿童预测 MetS 的有用生物标志物。我们的研究结果为 MetS 的治疗和预防提供了新的思路。
