Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China.
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, China.
Epilepsy Behav. 2021 Dec;125:108376. doi: 10.1016/j.yebeh.2021.108376. Epub 2021 Nov 12.
Social factors are believed to affect mental health in patients with epilepsy (PWE). However, there is still a lack of sufficient manifest proof, given the difficulty of exposing PWE to relatively consistent natural social environments with a low or high level of social interaction to study their significant role.
This single-center, longitudinal study was conducted via online questionnaires during the coronavirus disease 2019. PWE were recruited from downtown Wuhan and surrounding areas. The Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 were used to assess psychological status.
We analyzed 588 questionnaires completed by 294 PWE who participated in the dual survey. Under lockdown and reopening, the prevalence of anxiety was 13.6%/22.5%, and the prevalence of depression was 19.4%/34.0%. Raising children and seizure-related characteristics, including uncontrolled seizures, seizure exacerbation, seizure frequency ≥ 2/m, and changes in drug regimen, were risk factors in the first and second surveys. A high education level (OR = 1.946, 95% CI = 1.191-3.182), low life satisfaction (OR = 1.940, 95% CI = 1.007-3.737), worry about unanticipated seizures (OR = 2.147, 95% CI = 1.049-4.309), and worry about purchasing medication outside (OR = 2.063, 95% CI = 1.060-4.016) were risk factors for higher scores after reopening. Worry about unanticipated seizures (OR = 3.012, 95% CI = 1.302-6.965) and in-person medical consultation (OR = 2.319, 95% CI = 1.262-4.261) were related to newly diagnosed patients with psychological disorder after reopening.
We identified an association between social variables and epileptic psychiatric comorbidities.
社会因素被认为会影响癫痫患者（PWE）的心理健康。然而，由于难以让 PWE 暴露于社交互动水平高低不同的相对一致的自然社会环境中，以研究其重要作用，因此仍然缺乏充分的明确证据。
这是一项单中心、纵向研究，通过 2019 年冠状病毒病期间的在线问卷进行。从武汉市中心和周边地区招募 PWE。使用患者健康问卷-9 和广泛性焦虑症-7 评估心理状况。
我们分析了参与双次调查的 294 名 PWE 完成的 588 份问卷。在封锁和重新开放期间，焦虑症的患病率分别为 13.6%/22.5%，抑郁症的患病率分别为 19.4%/34.0%。抚养孩子和与癫痫相关的特征，包括未控制的癫痫发作、癫痫发作加重、发作频率≥2/月和药物方案改变，是第一次和第二次调查中的危险因素。高教育水平（OR=1.946，95%CI=1.191-3.182）、低生活满意度（OR=1.940，95%CI=1.007-3.737）、担心意外发作（OR=2.147，95%CI=1.049-4.309）和担心在外地购买药物（OR=2.063，95%CI=1.060-4.016）是重新开放后得分较高的危险因素。担心意外发作（OR=3.012，95%CI=1.302-6.965）和面对面医疗咨询（OR=2.319，95%CI=1.262-4.261）与重新开放后新诊断为心理障碍的患者有关。
我们发现社会变量与癫痫共病的精神障碍之间存在关联。
