Hussain Yaseen, Khan Haroon, Ahmad Imad, Efferth Thomas, Alam Waqas
College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China.
Department of Pharmacy, Abasyn University, Peshawar, Pakistan.
Phytomedicine. 2022 Jan;94:153830. doi: 10.1016/j.phymed.2021.153830. Epub 2021 Oct 30.
With growing global prevalence, cancer is a major cause of disease-related deaths. The understanding of the fundamental tumor pathology has contributed to the development of agents targeting oncogenic signaling pathways. Although these agents have increased survival for defined cancers, the therapeutic choices are still limited due to the development of drug resistance. CRISPR/Cas9 is a powerful new technology in cancer therapy by facilitating the identification of novel treatment targets and development of cell-based treatment strategies.
We focused on applications of the CRISPR/Cas9 system in cancer therapy and discuss nanoscale delivery of cytotoxic phytochemical targeting the CRISPR/Cas9 system.
Genome engineering has been significantly accelerated by the advancement of the CRISPR/Cas9 technique. Phytochemicals play a key role in treating cancer by targeting various mechanisms and pathways.
The use of CRISPR/Cas9 for nanoscale delivery of phytochemicals opens new avenues in cancer therapy. One of the main obstacles in the clinical application of CRISPR/Cas9 is safe and efficient delivery. As viral delivery methods have certain drawbacks, there is an urgent need to develop non-viral delivery systems for therapeutic applications.
随着全球患病率的不断上升，癌症是疾病相关死亡的主要原因。对肿瘤基本病理学的理解推动了靶向致癌信号通路药物的研发。尽管这些药物提高了特定癌症患者的生存率，但由于耐药性的产生，治疗选择仍然有限。CRISPR/Cas9是癌症治疗领域一项强大的新技术，有助于识别新的治疗靶点并开发基于细胞的治疗策略。
我们重点关注CRISPR/Cas9系统在癌症治疗中的应用，并探讨靶向CRISPR/Cas9系统的细胞毒性植物化学物质的纳米级递送。
CRISPR/Cas9技术的进步显著加速了基因组工程。植物化学物质通过靶向多种机制和途径在癌症治疗中发挥关键作用。
利用CRISPR/Cas9进行植物化学物质的纳米级递送为癌症治疗开辟了新途径。CRISPR/Cas9临床应用的主要障碍之一是安全有效的递送。由于病毒递送方法存在一定缺陷，迫切需要开发用于治疗应用的非病毒递送系统。
